Prefrontal Plasticity and Stress Inoculation-Induced Resilience

被引：60

作者：

Katz, Maor ^{[1
]}

Liu, Chunlei ^{[2
]}

Schaer, Marie ^{[3
,4
]}

Parker, Karen J. ^{[1
]}

Ottet, Marie-Christine ^{[3
]}

Epps, Averi ^{[1
]}

Buckmaster, Christine L. ^{[1
]}

Bammer, Roland ^{[2
]}

Moseley, Michael E. ^{[2
]}

Schatzberg, Alan F. ^{[1
]}

Eliez, Stephan ^{[3
]}

Lyons, David M. ^{[1
]}

机构：

[1] Stanford Univ, Dept Psychiat, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Radiol, Stanford, CA 94305 USA

[3] Univ Geneva, Div Child & Adolescent Psychiat, Geneva, Switzerland

[4] Swiss Fed Inst Technol, Signal Proc Inst, CH-1015 Lausanne, Switzerland

来源：

DEVELOPMENTAL NEUROSCIENCE | 2009年 / 31卷 / 04期

关键词：

Emotion regulation; Cognitive control; Fear; Curiosity; Cortisol; EARLY-LIFE STRESS; SURFACE-BASED ANALYSIS; HUMAN CEREBRAL-CORTEX; SQUIRREL-MONKEY; CORTICAL SURFACE; WHITE-MATTER; ENVIRONMENTAL ENRICHMENT; COORDINATE SYSTEM; BRAIN-DEVELOPMENT; BEHAVIOR;

D O I：

10.1159/000216540

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Coping with mild early life stress tends to make subsequent coping efforts more effective and therefore more likely to be used as a means of arousal regulation and resilience. Here we show that this developmental learning-like process of stress inoculation increases ventromedial prefrontal cortical volumes in peripubertal monkeys. Larger volumes do not reflect increased cortical thickness but instead represent surface area expansion of ventromedial prefrontal cortex. Expansion of ventromedial prefrontal cortex coincides with increased white matter myelination inferred from diffusion tensor magnetic resonance imaging. These findings suggest that the process of coping with early life stress increases prefrontal myelination and expands a region of cortex that broadly controls arousal regulation and resilience. Copyright (C) 2009 S. Karger AG, Basel

引用

页码：293 / 299

页数：7

共 66 条

[1] The prefrontal cortex and flexible Behavior [J].