Controlling 2-arachidonoylglycerol metabolism as an anti-inflammatory strategy

被引：53

作者：

Alhouayek, Mireille ^{[1
,2
]}

Masquelier, Julien ^{[1
]}

Muccioli, Giulio G. ^{[1
]}

机构：

[1] Catholic Univ Louvain, Louvain Drug Res Inst, Bioanal & Pharmacol Bioact Lipids Res Grp, B-1200 Brussels, Belgium

[2] Catholic Univ Louvain, Louvain Drug Res Inst, Med Chem Res Grp, B-1200 Brussels, Belgium

来源：

DRUG DISCOVERY TODAY | 2014年 / 19卷 / 03期

关键词：

EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; CANNABINOID RECEPTOR LIGANDS; HIGHLY SELECTIVE INHIBITORS; TRAUMATIC BRAIN-INJURY; MONOACYLGLYCEROL LIPASE; ENDOCANNABINOID; 2-ARACHIDONOYLGLYCEROL; MULTIPLE-SCLEROSIS; 2-ARACHIDONYL GLYCEROL; MICROGLIAL CELLS; HUMAN NEUTROPHILS;

D O I：

10.1016/j.drudis.2013.07.009

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The endocannabinoid system is implicated in, and regulates, several physiological processes, ranging from food intake and energy balance to pain and inflammation. 2-Arachidonoylglycerol (2-AG) is a full agonist at the cannabinoid receptors which classically mediate its effects. The activity of this bioactive lipid is dependent on its endogenous levels, which are tightly controlled by several hydrolases, monoacylglycerol lipase and alpha/beta-hydrolase domain 6 and 12. Moreover, 2-AG is also a substrate of cyclooxygenase-2, and this reaction leads to the formation of prostaglandin glycerol esters, the effects of which remain to be fully elucidated. In this review we discuss the multiple mechanisms by which 2-AG controls inflammation and the therapeutic potential of 2-AG metabolism inhibitors.

引用

页码：295 / 304

页数：10

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