Virus load during primary human immunodeficiency virus (HIV) type 1 infection is related to the severity of acute HIV illness in Kenyan women

被引：42

作者：

Lavreys, L

Baeten, JM

Overbaugh, J

Panteleeff, DD

Chohan, BH

Richardson, BA

Mandaliya, K

Ndinya-Achola, JO

Kreiss, JK

机构：

[1] Univ Washington, Seattle, WA 98104 USA

[2] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA

[3] Univ Nairobi, Nairobi, Kenya

[4] Coast Gen Prov Hosp, Mombasa, Kenya

来源：

CLINICAL INFECTIOUS DISEASES | 2002年 / 35卷 / 01期

关键词：

D O I：

10.1086/340862

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We evaluated the association between the severity of primary human immunodeficiency virus type 1 (HIV-1) illness and HIV-1 plasma virus load before seroconversion using stored plasma samples obtained from 74 prostitutes in Mombasa, Kenya. Fever, vomiting, headache, fatigue, arthralgia, myalgia, sore throat, skin rash, or being too sick to work were each associated with significantly higher virus loads before HIV-1 seroconversion, and each additional symptom or sign was associated with an increase in virus load of 0.4 log(10) copies/mL.

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页码：77 / 81

页数：5

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