Cancer Chemopreventive Effects of the Flavonoid-Rich Fraction Isolated from Papaya Seeds

被引:41
作者
Pathak, Neelam [1 ]
Khan, Saba [1 ,2 ]
Bhargava, Arpit [1 ,2 ,3 ]
Raghuram, Gorantla V. [1 ,2 ,3 ]
Jain, Deepika [1 ,2 ,3 ]
Panwar, Hariom [1 ,2 ,4 ]
Samarth, Ravindra M. [1 ,5 ]
Jain, Subodh K. [2 ]
Maudar, Kewal K. [1 ]
Mishra, Dinesh K. [6 ]
Mishra, Pradyumna K. [1 ,2 ,3 ]
机构
[1] Bhopal Mem Hosp & Res Ctr, Dept Res, Bhopal 462036, India
[2] Dr HS Gour Cent Univ, Sch Biol Sci, Sagar, India
[3] ACTREC, Tata Mem Ctr, Div Translat Res, Navi Mumbai 410210, India
[4] Vikram Univ, Sch Studies Zool & Biotechnol, Ujjain, Madhya Pradesh, India
[5] Univ Rajasthan, Dept Zool, Jaipur 302004, Rajasthan, India
[6] Guru Ghasidas Cent Univ, Dept Pharmaceut Sci, Bilaspur, India
来源
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 2014年 / 66卷 / 05期
关键词
MITOCHONDRIAL OXIDATIVE STRESS; CARICA-PAPAYA; DNA-DAMAGE; ISOCYANATE EXPOSURE; METHYL ISOCYANATE; NATURAL-PRODUCTS; PHYTOCHEMICALS; ANTIOXIDANTS; THERAPY; EXTRACT;
D O I
10.1080/01635581.2014.904912
中图分类号
R73 [肿瘤学];
学科分类号
100214 [肿瘤学];
摘要
Intervention to decelerate, arrest, or reverse the process of carcinogenesis by the use of either natural or synthetic agents individually or in combination has emerged as a promising and pragmatic medical approach to reduce cancer risk. In the present study, we examined the cancer chemopreventive potential of a flavonoid-rich fraction isolated from the seeds of Carica papaya, a plant traditionally referred to as papaw. The flavonoid-enriched benzene fraction of the aqueous extract exerted its anticancer properties in vitro through cytoprotection, antioxidative and antiinflammatory mechanisms and genoprotection in response to isocyanate-induced carcinogenicity. Medium-term anticarcinogenicity and 2-stage skin papillomagenesis studies conducted in benzopyrene-induced lung carcinogenesis and 7,12-dimethyl benz( a) anthracene-mediated skin papillomagenesis mouse models further validated our in vitro observations. This is the first demonstration of chemopreventive activities of papaya seed products, however, further studies to understand the subtle targets of intracellular signaling pathways, pharmacological profile and toxicological safety of this bioactive fraction are essential to pave the way for successful clinical translation. Our study supports the inverse association between dietary flavonoid intake and cancer risk.
引用
收藏
页码:857 / 871
页数:15
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