Some aspects of astroglial functions and aluminum implications for neurodegeneration
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作者:
Aremu, David A.
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Tottori Univ, Grad Sch Med Sci, Dept Social Med, Div Med Environmentol, Yonago, Tottori 6838503, JapanTottori Univ, Grad Sch Med Sci, Dept Social Med, Div Med Environmentol, Yonago, Tottori 6838503, Japan
Aremu, David A.
[1
]
Meshitsuka, Shunsuke
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机构:Tottori Univ, Grad Sch Med Sci, Dept Social Med, Div Med Environmentol, Yonago, Tottori 6838503, Japan
Meshitsuka, Shunsuke
机构:
[1] Tottori Univ, Grad Sch Med Sci, Dept Social Med, Div Med Environmentol, Yonago, Tottori 6838503, Japan
[2] Tottori Univ, Grad Sch Med Sci, Dept Biomed Sci, Div Integrat Biosci, Yonago, Tottori 6838503, Japan
The present decade had witnessed an unprecedented attention focused on glial cells as a result of their unusual physiological roles that are being unraveled. It is now known that, rather than being a mere supporter of neurons, astroglia are actively involved in their modulation. The aluminum hypothesis seems to have been laid to rest, probably due to contradictory epidemiological reports on it as a causative factor of neurodegenerative diseases. Surprisingly, newer scientific evidences continue to appear and recent findings have implicated astrocytes as the principal target of its toxic action. In view of the likely detrimental effects of the interaction between these two infamous partners in neuroscience on neurons and nervous system, we have reviewed some aspects of glia-neuron interaction and discussed the implications of aluminum-impaired astrocytic functions on neurodegeneration. Because sporadic causes still account for the majority of the neuro degenerative diseases of which Alzheimer's disease is the most prominent, it has been suggested that neurotoxicologists should not relent in screening for the environmental agents, such as aluminum, and that considerable attention should be given to glial cells in view of the likely implications of environmental toxicants on their never-imagined newly reported roles in the central nervous system (CNS). (c) 2006 Elsevier B.V. All rights reserved
机构:
Tottori Univ, Grad Sch Med Sci, Dept Biomed Sci, Div Integrat Biosci, Yonago, Tottori 6838503, JapanTottori Univ, Grad Sch Med Sci, Dept Biomed Sci, Div Integrat Biosci, Yonago, Tottori 6838503, Japan
Aremu, DA
Meshitsuka, S
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机构:
Tottori Univ, Grad Sch Med Sci, Dept Biomed Sci, Div Integrat Biosci, Yonago, Tottori 6838503, JapanTottori Univ, Grad Sch Med Sci, Dept Biomed Sci, Div Integrat Biosci, Yonago, Tottori 6838503, Japan
机构:
Tottori Univ, Grad Sch Med Sci, Dept Biomed Sci, Div Integrat Biosci, Yonago, Tottori 6838503, JapanTottori Univ, Grad Sch Med Sci, Dept Biomed Sci, Div Integrat Biosci, Yonago, Tottori 6838503, Japan
Aremu, DA
Meshitsuka, S
论文数: 0引用数: 0
h-index: 0
机构:
Tottori Univ, Grad Sch Med Sci, Dept Biomed Sci, Div Integrat Biosci, Yonago, Tottori 6838503, JapanTottori Univ, Grad Sch Med Sci, Dept Biomed Sci, Div Integrat Biosci, Yonago, Tottori 6838503, Japan