Some aspects of astroglial functions and aluminum implications for neurodegeneration

被引:20
作者
Aremu, David A. [1 ]
Meshitsuka, Shunsuke
机构
[1] Tottori Univ, Grad Sch Med Sci, Dept Social Med, Div Med Environmentol, Yonago, Tottori 6838503, Japan
[2] Tottori Univ, Grad Sch Med Sci, Dept Biomed Sci, Div Integrat Biosci, Yonago, Tottori 6838503, Japan
关键词
astroglial functions; neuron-astrocyte interaction; aluminum toxicity; neurodegenerative disease;
D O I
10.1016/j.brainresrev.2006.02.001
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The present decade had witnessed an unprecedented attention focused on glial cells as a result of their unusual physiological roles that are being unraveled. It is now known that, rather than being a mere supporter of neurons, astroglia are actively involved in their modulation. The aluminum hypothesis seems to have been laid to rest, probably due to contradictory epidemiological reports on it as a causative factor of neurodegenerative diseases. Surprisingly, newer scientific evidences continue to appear and recent findings have implicated astrocytes as the principal target of its toxic action. In view of the likely detrimental effects of the interaction between these two infamous partners in neuroscience on neurons and nervous system, we have reviewed some aspects of glia-neuron interaction and discussed the implications of aluminum-impaired astrocytic functions on neurodegeneration. Because sporadic causes still account for the majority of the neuro degenerative diseases of which Alzheimer's disease is the most prominent, it has been suggested that neurotoxicologists should not relent in screening for the environmental agents, such as aluminum, and that considerable attention should be given to glial cells in view of the likely implications of environmental toxicants on their never-imagined newly reported roles in the central nervous system (CNS). (c) 2006 Elsevier B.V. All rights reserved
引用
收藏
页码:193 / 200
页数:8
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