Therapeutic application of long-circulating liposomal glucocorticoids in auto-immune diseases and cancer

被引：52

作者：

Schiffelers, Raymond M. ^{[1
]}

Banciu, Manuela ^{[1
]}

Metselaar, Josbert M. ^{[1
]}

Storm, Gert ^{[1
]}

机构：

[1] Univ Utrecht, Dept Pharmaceut, Utrecht Inst Pharmaceut Studies, Utrecht, Netherlands

来源：

JOURNAL OF LIPOSOME RESEARCH | 2006年 / 16卷 / 03期

关键词：

liposomes; glucocorticoids; auto-immune diseases; cancer; angiogenesis;

D O I：

10.1080/08982100600851029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glucorticoids are potent drugs that have a multitude of pharmacological actions both at genomic and non-genomic levels. Many of the diseases in which glucorticoids are routinely administered are featured by angiogenesis and enhanced capillary permeability, permitting targeted delivery using long-circulating drug delivery systems. By encapsulation of glucorticoids in long-circulating liposomes, drug levels at the site of the pathology are markedly higher, increasing and prolonging therapeutic efficacy in models of rheumatoid arthritis, multiple sclerosis, and cancer.

引用

页码：185 / 194

页数：10

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