Synthesis and applications of chiral bis-THF in asymmetric synthesis

被引：18

作者：

Alexakis, A ^{[1
]}

Tomassini, A ^{[1
]}

Leconte, S ^{[1
]}

机构：

[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva 4, Switzerland

来源：

TETRAHEDRON | 2004年 / 60卷 / 42期

关键词：

asymmetric synthesis; chirality; diether; organolithium reagents; coordination;

D O I：

10.1016/j.tet.2004.07.091

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of enantiopure bis-THF is described, starting from D-mannitol. Bis-THF is used as chiral ligand for organolithium reagents in four different reactions. The enantioselectivity provided by this ligand is moderate, and the asymmetric induction is in line with the expected model. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：9479 / 9484

页数：6

共 55 条

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