Wittig olefination of methyl (1S,2R)-1-benzamido-2-formylcyclopropanecarboxylate. A powerful tool for the synthesis of new conformationally constrained cyclopropyl amino acids

被引：9

作者：

Cativiela, C

DiazdeVillegas, MD

Jimenez, AI

机构：

[1] Inst. de Cie. de Mat. de Aragon, Depto. de Quimica Organica, Universidad de Zaragoza-C.S.I.C.

来源：

TETRAHEDRON | 1996年 / 52卷 / 16期

关键词：

D O I：

10.1016/0040-4020(96)00218-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The behaviour of methyl (1S,2R)-1-benzamido-2-formylcyclopropanecarboxylate with stabilised and semi-stabilised ylids has been tested in order to evaluate its synthetic utility in the synthesis of cyclopropyl amino acids by Wittig olefination. Wittig adducts were further elaborated to obtain the corresponding cyclopropyl amino acids in high yields and enantiomerically pure form. Copyright (C) 1996 Elsevier Science Ltd

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页码：5881 / 5888

页数：8

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