Linking hydrophilic macromolecules to monodisperse magnetite (Fe3O4) nanoparticles via trichloro-s-triazine

被引：177

作者：

Xie, Jin

Xu, Chenjie

Xu, Zhichuan

Hou, Yanglong

Young, Kaylie L.

Wang, S. X.

Pourmond, N.

Sun, Shouheng ^{[1
]}

机构：

[1] Brown Univ, Dept Chem, Providence, RI 02912 USA

[2] Stanford Univ, Dept Mat Sci & Engn, Stanford, CA 94305 USA

[3] Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

来源：

CHEMISTRY OF MATERIALS | 2006年 / 18卷 / 23期

关键词：

D O I：

10.1021/cm061793c

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A simple approach to conjugate monodisperse Fe 3O 4 nanoparticles with various poly(ethylene glycol) (PEG)-based hydrophillic macromolecules through a readily available linker trichloro-s-triazine (TsT) was investigated. Fe 3O 4 nanoparticles have been tested vigorously for various biomedical applications because of their chemical stability and low toxicity. The monodisperse Fe 3O 4 nanoparticles were prepared by one-pot high temperature reductive decomposition of Fe(acac) 3 in oleylamine and benzyl ether. To functionalize the Fe 3O 4 nanoparticles with mPEG TsT was first used to react with mPEG 2000 at room temperature in anhydrous benzene. It was observed that TsT can be used as an easy linker to couple magnetic Fe 3O 4 nanoparticles with hydrophilic mPEG and TsT-based linking strategy can be extended to the coupling of various hydrophilic macromolecules.

引用

页码：5401 / 5403

页数：3

共 27 条

[1] Functionalisation of magnetic nanoparticles for applications in biomedicine [J].