The physiological response to cardiovascular 'orphan' G protein-coupled receptor agonists

被引:11
作者
Hare, JM [1 ]
Kass, DA
Stamler, JS
机构
[1] Johns Hopkins Med Inst, Dept Med, Div Cardiol, Baltimore, MD 21287 USA
[2] Duke Univ, Med Ctr, Howard Hughes Med Inst, Durham, NC 27710 USA
[3] Duke Univ, Med Ctr, Dept Med Cardiol, Durham, NC 27710 USA
[4] Duke Univ, Med Ctr, Div Pulm, Durham, NC 27710 USA
关键词
D O I
10.1038/15193
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cardiac pressor agents typically reduce the amount of blood pumped with each heartbeat. Cardiovascular hemodynamic principles can show whether such a response is physiologic or maladaptive.
引用
收藏
页码:1241 / 1242
页数:2
相关论文
共 14 条
  • [1] Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14
    Ames, RS
    Sarau, HM
    Chambers, JK
    Willette, RN
    Alyar, NV
    Romanic, AM
    Louden, CS
    Foley, JJ
    Sauermelch, CF
    Coatney, RW
    Ao, ZH
    Disa, J
    Holmes, SD
    Stadel, JM
    Martin, JD
    Liu, WS
    Glover, GI
    Wilson, S
    McNulty, DE
    Ellis, CE
    Elshourbagy, NA
    Shabon, U
    Trill, JJ
    Hay, DWP
    Ohlstein, EH
    Bergsma, DJ
    Douglas, SA
    [J]. NATURE, 1999, 401 (6750) : 282 - 286
  • [2] Intravenous allopurinol decreases myocardial oxygen consumption and increases mechanical efficiency in dogs with pacing-induced heart failure
    Ekelund, UEG
    Harrison, RW
    Shokek, O
    Thakkar, RN
    Tunin, RS
    Senzaki, H
    Kass, DA
    Marbán, E
    Hare, JM
    [J]. CIRCULATION RESEARCH, 1999, 85 (05) : 437 - 445
  • [3] Acute cardiovascular effects of OPC-18790 in patients with congestive heart failure - Time- and dose-dependence analysis based on pressure-volume relations
    Feldman, MD
    Pak, PH
    Wu, CC
    Haber, HL
    Heesch, CM
    Bergin, JD
    Powers, ER
    Cowart, TD
    Johnson, W
    Feldman, AM
    Kass, DA
    [J]. CIRCULATION, 1996, 93 (03) : 474 - 483
  • [4] GEORGAKOPOULOS D, 1998, AM J PHYSIOL-HEART C, V274, P1416
  • [5] An open-label dose escalation study of the nitric oxide synthase inhibitor, NG-methyI-L-arginine hydrochloride (546C88), in patients with septic shock
    Grover, R
    Zaccardelli, D
    Colice, G
    Guntupalli, K
    Watson, D
    Vincent, JL
    [J]. CRITICAL CARE MEDICINE, 1999, 27 (05) : 913 - 922
  • [6] KASS DA, 1987, CIRCULATION, V76, P1421
  • [7] EFFECTIVE ARTERIAL ELASTANCE AS INDEX OF ARTERIAL VASCULAR LOAD IN HUMANS
    KELLY, RP
    TING, CT
    YANG, TM
    LIU, CP
    MAUGHAN, WL
    CHANG, MS
    KASS, DA
    [J]. CIRCULATION, 1992, 86 (02) : 513 - 521
  • [8] CARDIAC AND PERIPHERAL CIRCULATORY RESPONSES TO ANGIOTENSIN AND VASOPRESSIN IN DOGS
    LEE, RW
    STANDAERT, S
    LANCASTER, LD
    BUCKLEY, D
    GOLDMAN, S
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1988, 82 (02) : 413 - 419
  • [9] Identification of the natural ligand of an orphan G-protein-coupled receptor involved in the regulation of vasoconstriction
    Nothacker, HP
    Wang, ZW
    McNeil, AM
    Saito, Y
    Merten, S
    O'Dowd, B
    Duckles, SP
    Civelli, O
    [J]. NATURE CELL BIOLOGY, 1999, 1 (06) : 383 - 385
  • [10] Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
    Sakurai, T
    Amemiya, A
    Ishii, M
    Matsuzaki, I
    Chemelli, RM
    Tanaka, H
    Williams, SC
    Richardson, JA
    Kozlowski, GP
    Wilson, S
    Arch, JRS
    Buckingham, RE
    Haynes, AC
    Carr, SA
    Annan, RS
    McNulty, DE
    Liu, WS
    Terrett, JA
    Elshourbagy, NA
    Bergsma, DJ
    Yanagisawa, M
    [J]. CELL, 1998, 92 (04) : 573 - 585