Bisphosphonate-associated arthritis

被引：16

作者：

Diaz-Borjon, Alejandro ^{[1
]}

Seyler, Thorsten M. ^{[1
]}

Chen, Natasha L. ^{[1
]}

Lim, S. Sam ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Med, Div Rheumatol, Atlanta, GA 30303 USA

来源：

JCR-JOURNAL OF CLINICAL RHEUMATOLOGY | 2006年 / 12卷 / 03期

关键词：

bisphosphonates; acute-phase response; arthritis; breast carcinoma; proinflammatory cytokine; adverse effect;

D O I：

10.1097/01.rhu.0000221796.06383.4e

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

We present a case of arthritis apparently induced by the administration of intravenous bisphosphonates in a 51-year-old white woman with metastatic breast carcinoma. She presented with bilateral knee pain and effusions on 2 separate occasions after receiving aminobisphosphonates. Synovial fluid analysis was negative for infection. metastasis, or crystals. Her symptoms resolved after the medication was discontinued and recurred after the patient was rechallenged with a medication from the same drug class. The administration of aminobisphosphonates has been associated with an acute-phase response in several in vivo studies. The mechanism of action is thought to be that aminobisphosphonates transiently stimulate the production of proinflammatory cytokines such as interleukin-1, interleukin-6, and tumor necrosis factor-alpha. Rheumatologists should be aware of this possible cause of arthropathy.

引用

页码：131 / 133

页数：3

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