An overall picture of chemokine receptors: Basic research and drug development

被引：17

作者：

Chen, L

Pei, G

Zhang, WB

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Shanghai 200031, Peoples R China

[2] Shanghai TARGETDRUG Co Ltd, Shanghai 200233, Peoples R China

来源：

CURRENT PHARMACEUTICAL DESIGN | 2004年 / 10卷 / 09期

关键词：

chemokine receptor; G protein coupled receptor; signal transduction; ligand; agonist; antagonist; chemotaxis; drug discovery;

D O I：

10.2174/1381612043452749

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Chemokine receptors belong to the transmembrane G protein coupled receptor (GPCR) family. Although a major physiological role of chemokine receptors is for host defense by recruitment of lymphocytes to inflammatory sites, they are now found to be involved in more processes such as virus infection, tumor genesis and metastasis, and embryologic development. In this review, we show an overall picture of chemokine receptors in structure, signal transduction and modulation, physiological and pathological roles, and applying chemokine receptors for drug discovery.

引用

页码：1045 / 1055

页数：11

共 112 条

[1] HIV-1 Tat protein mimicry of chemokines [J].

Albini, A ;

Ferrini, S ;

Benelli, R ;

Sforzini, S ;

Giunciuglio, D ;

Aluigi, MG ;

Proudfoot, AEI ;

Alouani, S ;

Wells, TNC ;

Mariani, G ;

Rabin, RL ;

Farber, JM ;

Noonan, DM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (22) :13153-13158

[2] Differential regulation of G-protein-mediated signaling by chemokine receptors [J].

Arai, H ;

Charo, IF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (36) :21814-21819

[3] Constitutive activation of CCR5 and CCR2 induced by conformational changes in the conserved TXP motif in transmembrane helix 2 [J].

Arias, DA ;

Navenot, JM ;

Zhang, WB ;

Broach, J ;

Peiper, SC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (38) :36513-36521

[4]

Bacon KB, 1998, J IMMUNOL, V160, P1894

[5] NEUTROPHIL-ACTIVATING PEPTIDE-1 INTERLEUKIN-8, A NOVEL CYTOKINE THAT ACTIVATES NEUTROPHILS [J].

BAGGIOLINI, M ;

WALZ, A ;

KUNKEL, SL .

JOURNAL OF CLINICAL INVESTIGATION, 1989, 84 (04) :1045-1049

[6] Chemokines and leukocyte traffic [J].

Baggiolini, M .

NATURE, 1998, 392 (6676) :565-568

[7] Tyrosine phosphorylation-mediated signal transduction in MCP-1-induced macrophage activation: role for receptor dimerization, focal adhesion protein complex and JAK/STAT pathway [J].

Biswas, SK ;

Sodhi, A .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2002, 2 (08) :1095-1107

[8] In vitro activation of murine peritoneal macrophages by monocyte chemoattractant protein-1:: Upregulation of CD11b, production of proinflammatory cytokines, and the signal transduction pathway [J].

Biswas, SK ;

Sodhi, A .

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2002, 22 (05) :527-538

[9] Palmitoylation of CCR5 is critical for receptor trafficking and efficient activation of intracellular signaling pathways [J].

Blanpain, C ;

Wittamer, V ;

Vanderwinden, JM ;

Boom, A ;

Renneboog, B ;

Lee, B ;

Le Poul, E ;

El Asmar, L ;

Govaerts, C ;

Vassart, G ;

Doms, RW ;

Parmentier, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (26) :23795-23804

[10] N-linked glycosylation of CXCR4 masks coreceptor function for CCR5-dependent human immunodeficiency virus type 1 isolates [J].

Chabot, DJ ;

Chen, H ;

Dimitrov, DS ;

Broder, CC .

JOURNAL OF VIROLOGY, 2000, 74 (09) :4404-4413

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