Some Basic Aspects of HLA-G Biology

被引：76

作者：

Alegre, Estibaliz ^{[1
]}

Rizzo, Roberta ^{[2
]}

Bortolotti, Daria ^{[2
]}

Fernandez-Landazuri, Sara ^{[1
]}

Fainardi, Enrico ^{[3
]}

Gonzalez, Alvaro ^{[1
]}

机构：

[1] Univ Navarra Clin, Dept Biochem, Pamplona, Spain

[2] Univ Ferrara, Dept Med Sci, Sect Microbiol & Med Genet, I-44100 Ferrara, Italy

[3] St Anna Hosp, Neuroradiol Unit, Ferrara, Italy

来源：

JOURNAL OF IMMUNOLOGY RESEARCH | 2014年 / 2014卷

关键词：

ANTIGEN-PRESENTING CELLS; MHC CLASS-I; NATURAL-KILLER-CELLS; IFN-GAMMA PRODUCTION; G GENE-EXPRESSION; G MESSENGER-RNA; G MOLECULES; G ISOFORMS; T-CELL; MONOCLONAL-ANTIBODIES;

D O I：

10.1155/2014/657625

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Human leukocyte antigen-G (HLA-G) is a low polymorphic nonclassical HLA-I molecule restrictively expressed and with suppressive functions. HLA-G gene products are quite complex, with seven HLA-G isoforms, four membrane bound, and other three soluble isoforms that can suffer different posttranslational modifications or even complex formations. In addition, HLA-G has been described included in exosomes. In this review we will focus on HLA-G biochemistry with special emphasis to the mechanisms that regulate its expression and how the protein modifications affect the quantification in biological fluids.

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页数：10

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