The immune network in pancreatic cancer development and progression

被引：162

作者：

Woermann, S. M. ^{[1
]}

Diakopoulos, K. N. ^{[1
]}

Lesina, M. ^{[1
]}

Alguel, H. ^{[1
]}

机构：

[1] Tech Univ Munich, Klinikum Rechts Isar, Med Klin, D-81675 Munich, Germany

来源：

ONCOGENE | 2014年 / 33卷 / 23期

关键词：

pancreatic ductal adenocarcinoma; tumor microenvironment; immune system; cytokines; pattern recognition receptors; immune cells; REGULATORY T-CELLS; TUMOR-INFILTRATING LYMPHOCYTES; CIRCULATING DENDRITIC CELLS; KAPPA-B ACTIVATION; GROWTH-FACTOR-BETA; SUPPRESSOR-CELLS; MAST-CELLS; INFLAMMATORY CELLS; CARCINOMA-CELLS; MURINE MODEL;

D O I：

10.1038/onc.2013.257

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The presence of stromal desmoplasia is a hallmark of spontaneous pancreatic ductal adenocarcinoma, forming a unique microenvironment that comprises many cell types. Only recently, the immune system has entered the pathophysiology of pancreatic ductal adenocarcinoma development. Tumor cells in the pancreas seem to dysbalance the immune system, thus facilitating spontaneous cancer development. This review will try to assemble all relevant data to demonstrate the implications of the immune network on spontaneous cancer development.

引用

页码：2956 / 2967

页数：12

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