Tyrosine-phosphorylation: thirty years and counting

被引:518
作者
Hunter, Tony [1 ]
机构
[1] Salk Inst Biol Studies, La Jolla, CA 92037 USA
关键词
CELL LUNG-CANCER; KINASE REQUIREMENTS; STRUCTURAL BASIS; SIGNAL-TRANSDUCTION; SH2; DOMAIN; RECEPTOR; MUTATIONS; PHOSPHATASES; RECOGNITION; INHIBITION;
D O I
10.1016/j.ceb.2009.01.028
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In the 30 years since its discovery, tyrosine phosphorylation has emerged as a fundamentally important mechanism of signal transduction and regulation in all eukaryotic cells, governing many processes, including cell proliferation, cell cycle progression, metabolic homeostasis, transcriptional activation, neural transmission, differentiation and development, and aging. Perturbations in tyrosine phosphorylation underlie many human diseases, and in particular cancer, and this has prompted the development of inhibitors of tyrosine kinases implicated in disease, a number of which have been approved for clinical use. The following is a brief personal reflection on some of the salient findings over the past 30 years that led to the development of tyrosine kinase inhibitors for disease therapy.
引用
收藏
页码:140 / 146
页数:7
相关论文
共 49 条
[1]   Protein tyrosine phosphatases in the human genome [J].
Alonso, A ;
Sasin, J ;
Bottini, N ;
Friedberg, I ;
Friedberg, I ;
Osterman, A ;
Godzik, A ;
Hunter, T ;
Dixon, J ;
Mustelin, T .
CELL, 2004, 117 (06) :699-711
[2]   Phosphoproteome analysis of HeLa cells using stable isotope labeling with amino acids in cell culture (SILAC) [J].
Amanchy, R ;
Kalume, DE ;
Iwahori, A ;
Zhong, J ;
Pandey, A .
JOURNAL OF PROTEOME RESEARCH, 2005, 4 (05) :1661-1671
[3]  
BAE JH, 2009, CELL IN PRESS
[4]   The selectivity of protein kinase inhibitors: a further update [J].
Bain, Jenny ;
Plater, Lorna ;
Elliott, Matt ;
Shpiro, Natalia ;
Hastie, C. James ;
Mclauchlan, Hilary ;
Klevernic, Iva ;
Arthur, J. Simon C. ;
Alessi, Dario R. ;
Cohen, Philip .
BIOCHEMICAL JOURNAL, 2007, 408 :297-315
[5]   Kinase requirements in human cells: II. Genetic interaction screens identify kinase requirements following HPV16 E7 expression in cancer cells [J].
Baldwin, Amy ;
Li, Wenliang ;
Grace, Miranda ;
Pearlberg, Joseph ;
Harlow, Ed ;
Muenger, Karl ;
Grueneberg, Dorre A. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (43) :16478-16483
[6]   Mutational analysis of the tyrosine kinome in colorectal cancers [J].
Bardelli, A ;
Parsons, DW ;
Silliman, N ;
Ptak, J ;
Szabo, S ;
Saha, S ;
Markowitz, S ;
Willson, JKV ;
Parmigiani, G ;
Kinzler, KW ;
Vogelstein, B ;
Velculescu, VE .
SCIENCE, 2003, 300 (5621) :949-949
[7]   Oncogenic kinase signalling [J].
Blume-Jensen, P ;
Hunter, T .
NATURE, 2001, 411 (6835) :355-365
[8]   Kinase requirements in human cells: III. Altered kinase requirements in VHL-/- cancer cells detected in a pilot synthetic lethal screen [J].
Bommi-Reddy, Archana ;
Almeciga, Ingrid ;
Sawyer, Jacqueline ;
Geisen, Christoph ;
Li, Wenliang ;
Harlow, Ed ;
Kaelin, William G., Jr. ;
Grueneberg, Dorre A. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (43) :16484-16489
[9]   SAP couples Fyn to SLAM immune receptors [J].
Chan, B ;
Lanyi, A ;
Song, HK ;
Griesbach, J ;
Simarro-Grande, M ;
Poy, F ;
Howie, D ;
Sumegi, J ;
Terhorst, C ;
Eck, MJ .
NATURE CELL BIOLOGY, 2003, 5 (02) :155-160
[10]   A crystallographic snapshot of tyrosine trans-phosphorylation in action [J].
Chen, Huaibin ;
Xu, Chong-Feng ;
Ma, Jinghong ;
Eliseenkova, Anna V. ;
Li, Wanqing ;
Pollock, Pamela M. ;
Pitteloud, Nelly ;
Miller, W. Todd ;
Neubert, Thomas A. ;
Mohammadi, Moosa .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (50) :19660-19665