Mechanisms of Diarrhea in Inflammatory Bowel Diseases

被引：49

作者：

Binder, Henry J. ^{[1
]}

机构：

[1] Yale Univ, Dept Internal Med, New Haven, CT 06520 USA

来源：

MOLECULAR STRUCTURE AND FUNCTION OF THE TIGHT JUNCTION: FROM BASIC MECHANISMS TO CLINICAL MANIFESTATIONS | 2009年 / 1165卷

关键词：

diarrhea; ulcerative colitis; Crohn's disease; inflammation; HUMAN COLON; ELECTROLYTE TRANSPORT; ULCERATIVE-COLITIS; SODIUM-ABSORPTION; CROHNS-DISEASE; ION-TRANSPORT; WATER; EXPRESSION; SECRETION; INTESTINE;

D O I：

10.1111/j.1749-6632.2009.04039.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Diarrhea is a frequent symptom/sign in patients with ulcerative colitis and Crohn's disease (inflammatory bowel diseases), and several different mechanisms likely account for this diarrhea. As treatment of diarrhea is dependent on the pathogenetic process(es) responsible for diarrhea, increased understanding of the pathophysiology of diarrhea will help improve therapy. Inflammation is central to the diarrhea in patients with ulcerative colitis, while in Crohn's disease both inflammatory and noninflammatory mechanisms are responsible. This presentation summarizes the pathophysiology of diarrhea in both ulcerative colitis and Crohn's disease.

引用

页码：285 / 293

页数：9

共 23 条

[1]

Cytokine-dependent transcriptional down-regulation of epithelial sodium channel in ulcerative colitis [J].