Autophagy genes mediate the effect of calcineurin on life span in C. elegans

被引：46

作者：

Dwivedi, Meenakshi ^{[1
,2
]}

Song, Hyun-Ok ^{[3
]}

Ahnn, Joohong ^{[1
]}

机构：

[1] Hanyang Univ, Dept Life Sci, Seoul 133791, South Korea

[2] Hanyang Univ, RINS, Seoul 133791, South Korea

[3] Gwangju Inst Sci & Technol, Dept Life Sci, Kwangju, South Korea

来源：

AUTOPHAGY | 2009年 / 5卷 / 05期

关键词：

calcineurin; autophagy; life span; beclin; 1; Atg-7; GFP::LGG-1 expression; DEPENDENT PROTEIN PHOSPHATASE; CALMODULIN; LONGEVITY;

D O I：

10.4161/auto.5.5.8157

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Calcineurin (CaN) is a serine/threonine phosphatase, activated by Ca2+/calmodulin (Ca2+/CaM). CaN is known to regulate various cellular responses in different organisms. A recent study showed an extended life span in the calcineurin mutants of C elegans. In this study, we report that calcineurin defective strains exhibit enhanced autophagy. In addition, we found two essential autophagy genes (bec-1 and atg-7) are required for the life-span extension in calcineurin null mutants [cnb-1(jh103)]. Thus, for the first time we suggest that autophagy genes are required for the life-span regulation in calcineurin defective C. elegans strains.

引用

页码：604 / 607

页数：4

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