A straightforward synthesis of (2S,3R)-3-hydroxyproline and trans-(2R,3S)-2-hydroxymethyl-3-hydroxypyrrolidine

被引：27

作者：

DellUomo, N

DiGiovanni, MC

Misiti, D

Zappia, G

DelleMonache, G

机构：

[1] UNIV ROMA LA SAPIENZA, DIPARTIMENTO STUDI CHIM & TECNOL SOSTANZE BIOL AT, I-00185 ROME, ITALY

[2] UNIV CATTOLICA SACRO CUORE, IST CHIM, CTR STUDIO CHIM RECETTORI & MOLEC BIOL ATTIVE, I-00168 ROME, ITALY

来源：

TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 01期

关键词：

D O I：

10.1016/0957-4166(95)00434-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A stereocontrolled synthesis of (2S,3R)-3-hydroxyproline 1, and trans-(2R,3S)-2-hydroxymethyl-3-hydroxypyrrolidine 2 has been achieved in 21% and 38% yield via the homochiral 4,5-disubstituted oxazolidin-2-one 3. The trans relationship in 2 has been introduced by a modified Mitsunobu reaction.

引用

页码：181 / 188

页数：8

共 39 条

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