Structural brain alterations following 5 days of intervention:: Dynamic aspects of neuroplasticity

被引:251
作者
May, A.
Hajak, G.
Gaenssbauer, S.
Steffens, T.
Langguth, B.
Kleinjung, T.
Eichhammer, P.
机构
[1] Univ Hamburg, Dept Syst Neurosci, D-20246 Hamburg, Germany
[2] Univ Regensburg, Dept Psychiat & Psychotherapy, D-93059 Regensburg, Germany
[3] Univ Regensburg, Dept Neurol, D-93059 Regensburg, Germany
[4] Univ Regensburg, Dept ENT, D-93059 Regensburg, Germany
关键词
auditory cortex; plasticity; rTMS; voxel-based morphometry;
D O I
10.1093/cercor/bhj138
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Activation-dependent brain plasticity in humans on a structural level has been demonstrated in adults after 3 months of training a visiomotor skill. The exact timescale of usage-dependent structural changes, whether days, months, or years, is, however, still debated. A better understanding of the temporal parameters may help elucidate to what extent this type of cortical plasticity contributes to fast adapting cortical processes that may be relevant to learning and effects of treatments. Using voxel-based morphometry, we are able to show that repetitive transcranial magnetic stimulation delivered to the superior temporal cortex causes macroscopic cortical changes in gray matter (GM) in the auditory cortex as early as within 5 days of continuous intervention. These structural alterations are mirrored by changes in cortical evoked potentials attributed to the GM changes and demonstrate the rapid dynamics of these processes, which occur within a time range characteristic for the onset of behavioral effects induced by a variety of treatment methods for neuropsychiatric diseases. Our finding suggests that cortical plasticity on a structural level in adult humans is already detectable after 1 week, which provides support for fast adjusting neuronal systems, such as spine and synapse turnover, and contradicts slow evolving mechanisms, such as neuronal or glial cell genesis.
引用
收藏
页码:205 / 210
页数:6
相关论文
共 38 条
[1]  
Ashburner J, 2000, HUM BRAIN MAPP, V9, P212, DOI 10.1002/(SICI)1097-0193(200004)9:4<212::AID-HBM3>3.0.CO
[2]  
2-#
[3]   Voxel-based morphometry - The methods [J].
Ashburner, J ;
Friston, KJ .
NEUROIMAGE, 2000, 11 (06) :805-821
[4]   Repeated premotor rTMS leads to cumulative plastic changes of motor cortex excitability in humans [J].
Bäumer, T ;
Lange, R ;
Liepert, J ;
Weiller, C ;
Siebner, HR ;
Rothwell, JC ;
Münchau, A .
NEUROIMAGE, 2003, 20 (01) :550-560
[5]   Simulated apoptosis/neurogenesis regulates learning and memory capabilities of adaptive neural networks [J].
Chambers, RA ;
Potenza, MN ;
Hoffman, RE ;
Miranker, W .
NEUROPSYCHOPHARMACOLOGY, 2004, 29 (04) :747-758
[6]   Long-term modifications of synaptic efficacy in the human inferior and middle temporal cortex [J].
Chen, WR ;
Lee, SH ;
Kato, K ;
Spencer, DD ;
Shepherd, GM ;
Williamson, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (15) :8011-8015
[7]  
Destexhe A, 1998, J NEUROPHYSIOL, V79, P999
[8]   Neuroplasticity: Changes in grey matter induced by training - Newly honed juggling skills show up as a transient feature on a brain-imaging scan [J].
Draganski, B ;
Gaser, C ;
Busch, V ;
Schuierer, G ;
Bogdahn, U ;
May, A .
NATURE, 2004, 427 (6972) :311-312
[9]   Neuronavigated repetitive transcranial magnetic stimulation in patients with tinnitus: A short case series [J].
Eichhammer, P ;
Langguth, B ;
Marienhagen, J ;
Kleinjung, T ;
Hajak, G .
BIOLOGICAL PSYCHIATRY, 2003, 54 (08) :862-865
[10]  
EVANS AC, 1994, NATO ADV SCI INST SE, V264, P263