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A meta-analysis of cardiopulmonary resuscitation with and without the administration of thrombolytic agents

被引：49
作者：
Li, Xin
Fu, Qing-ling
Jing, Xiao-li
Li, Yu-jie
Zhan, Hong
Ma, Zhong-fu
Liao, Xiao-xing [1 ]
机构：
[1] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Emergency, Guangzhou 510080, Guangdong, Peoples R China
[2] Univ Hong Kong, Dept Anat, Hong Kong, Peoples R China
来源：
RESUSCITATION | 2006年 / 70卷 / 01期
关键词：
cardiopulmonary resuscitation (CPR); drug therapy; thrombolysis;
D O I：
10.1016/j.resuscitation.2005.11.016
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Objective: To pool data on the role of thrombolytic agents in cardiopulmonary resuscitation (CPR) and evaluate the efficacy and safety of thrombolysis. Materials and methods: The clinical studies in MEDLINE database from 1966 to August 2004 that studied the efficacy and safety in CPR with and without treatment with thrombolytic agents were assessed by a meta-analysis performed to evaluate the effect of the treatment. Results: A total of eight papers evaluating the effect of thrombolysis in CPR were identified. This meta-analysis showed that thrombolytic agents significantly improved the rate of return of spontaneous circulation, 24h survival rate, survival to discharge and long-term neurological function in patients treated with CPR (p < 0.01). However, the patients receiving thrombolysis had a risk of severe bleeding (P < 0.01). Conclusion: Thrombolytic agents during CPR can improve the survival rate to discharge and neurological function. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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收藏
页码：31 / 36
页数：6
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