Chelation-assisted β-alkylation of α,β-unsaturated ketone using Rh(I) catalyst and dialkyl amine

被引：39

作者：

Jun, CH ^{[1
]}

Moon, CW ^{[1
]}

Kim, YM ^{[1
]}

Lee, H ^{[1
]}

Lee, JH ^{[1
]}

机构：

[1] Yonsei Univ, Dept Chem, Seoul 120749, South Korea

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 23期

关键词：

C-H activation; alkylation; beta; gamma-unsaturated ketone; Wilkinson catalyst;

D O I：

10.1016/S0040-4039(02)00769-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new Rh(I)-catalyzed beta-alkylation of 4-phenyl-3-buten-2-one (1) was developed by utilizing diethylamine (5a) as a chelation-assistant tool. The key feature of this reaction is the vinyl C-H activation driven by amine-assisted cyclometalation to give the beta,gamma-unsaturated ketones 7 as a major product. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：4233 / 4236

页数：4

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