Methionine and cysteine metabolism in Fasciola hepatica

被引:3
作者
Bankov, I
Timanova, A
Barrett, J
机构
[1] UNIV WALES,INST BIOL SCI,ABERYSTWYTH SY23 3DA,DYFED,WALES
[2] BULGARIAN ACAD SCI,INST EXPT PATHOL & PARASITOL,BU-1113 SOFIA,BULGARIA
关键词
Fasciola hepatica; methyltetrahydrofolate-homocysteine methyltransferase (methionine synthase); cystathionine-beta-synthase; gamma-cystathionase; TH4-tetrahydrofolate;
D O I
10.1016/S0020-7519(96)00131-2
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Radiolabel from the methyl groups of serine and methyltetrahydrofolate was readily incorporated into methionine in adult Fasciola hepatica, and a substantial proportion of the label from [S-35]methionine appeared in cysteine. The data suggest that methionine synthesis is via methyltetrahydrofolate-homocysteine methyltransferase and that there is cysteine synthesis from methionine. Cystathionine-beta-synthase and gamma-cystathionase activities were demonstrated in homogenates. Copyright (C) 1996 Australian Society for Parasitology. Published by Elsevier Science Ltd.
引用
收藏
页码:1401 / 1404
页数:4
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