PI3K/Akt pathway involving into apoptosis and invasion in human colon cancer cells LoVo

被引：81

作者：

Jiang, Qun Guang ^{[1
]}

Li, Tai Yuan ^{[1
]}

Liu, Dong Ning ^{[1
]}

Zhang, Hai Tao ^{[1
]}

机构：

[1] Nanchang Univ, Gastrointestinal Surg Dept, Affiliated Hosp 1, Nanchang 330006, Jiangxi, Peoples R China

来源：

MOLECULAR BIOLOGY REPORTS | 2014年 / 41卷 / 05期

关键词：

Curcumin; LoVo; PI3K/Akt pathway; Colon cancer; CHEMOPREVENTIVE AGENTS; CASPASE ACTIVATION; CARCINOMA CELLS; CYTOCHROME-C; IN-VITRO; CURCUMIN; GROWTH; 5-FLUOROURACIL; INHIBITION; EXPRESSION;

D O I：

10.1007/s11033-014-3198-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

In this study we determined the effects of Curcumin on human colon cancer cells line LoVo. We found that Curcumin significantly inhibited the proliferation, migration and invasion, and clone formation of LoVo cells in a dose-dependent manner. Curcumin also dose-dependently reduced the phosphorylation of proteins Akt and increased expression levels of the genes caspase-3, cytochrome-c, Bax mRNA in LoVo cells. In addition, Curcumin dose-dependently decreased gene Bcl-2 mRNA expression. Similar results were observed in LoVo cells treated with LY294002. These in vitro studies suggest that Curcumin may play its anti-cancer actions partly via suppressing PI3K/Akt signal pathway in LoVo cells.

引用

页码：3359 / 3367

页数：9

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