Presynaptic function

Changing the strength of synapses is key to the adaptive modifications of what neuronal circuits compute. Unsurprisingly, many different mechanisms have evolved to alter synaptic strength. Some of these mechanisms depend on the history of synaptic use, others reflect the activity of modulatory neurons that are controlled through neural computations, and still others involve more global measures of neural activity. The molecular machinery synapses use to convey information from one neuron to the next not only plays an essential part in brain function but also is at the basis of processes that are vital to all cells. Because membrane fusion events at synapses are so precisely controlled, synapses offer an especially favorable system in which to study these basic processes. Here, I review some of the recent progress that has been made in understanding both how synaptic strength is regulated and how fundamental cell biological mechanisms are used to accomplish neuronal intercommunication.