Expanding role of AMPK in endocrinology

被引：172

作者：

Kola, Blerina

Boscaro, Marco

Rutter, Guy A.

Grossman, Ashley B.

Korbonits, Marta ^{[1
]}

机构：

[1] Univ London, Barts & London Queen Marys Sch Med & Dent, Dept Endocrinol, London EC1M 6BQ, England

[2] Univ Ancona, Div Endocrinol, Dept Internal Med, Ancona, Italy

[3] Univ Bristol, Sch Med Sci, Dept Biochem, Bristol BS8 1TD, Avon, England

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2006年 / 17卷 / 05期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1016/j.tem.2006.05.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adenosine 5' monophosphate-activated protein kinase (AMPK) is a regulator of cellular and systemic energy homeostasis. It mediates some of the effects of peripheral hormones such as leptin, ghrelin and adiponectin, and it is involved in the insulin-sensitizing role of the antidiabetic drug metformin. There is increasing evidence that AMPK has a central role in mediating the appetite-modulating and metabolic effects of many other hormones and substances, including the cannabinoids. Recent studies have illustrated the interaction between hormones and AMPK, and highlighted AMPK as a potential target for the development of tissuespecific AMPK modulators in the treatment of obesity and the metabolic syndrome.

引用

收藏

页码：205 / 215

页数：11

相关论文

共 88 条

[21] Endocannabinoids as mediators in the heart: a potential target for therapy of remodelling after myocardial infarction? [J].

Hiley, CR ;

Ford, WR .

BRITISH JOURNAL OF PHARMACOLOGY, 2003, 138 (07) :1183-1184

[22] Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase α-subunits in heart via hierarchical phosphorylation of Ser485/491 [J].

Horman, S ;

Vertommen, D ;

Heath, R ;

Neumann, D ;

Mouton, V ;

Woods, A ;

Schlattner, U ;

Walliman, T ;

Carling, D ;

Hue, L ;

Rider, MH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (09) :5335-5340

[23] The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases [J].

Hurley, RL ;

Anderson, KA ;

Franzone, JM ;

Kemp, BE ;

Means, AR ;

Witters, LA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (32) :29060-29066

[24] β-Adrenoceptors, but not α-adrenoceptors, stimulate AMP-activated protein kinase in brown adipocytes independently of uncoupling protein-1 [J].

Hutchinson, DS ;

Chernogubova, E ;

Dallner, OS ;

Cannon, B ;

Bengtsson, T .

DIABETOLOGIA, 2005, 48 (11) :2386-2395

[25] Adiponectin-mediated stimulation of AMP-activated protein kinase (AMPK) in pancreatic beta cells [J].

Huypens, P ;

Moens, K ;

Heimberg, H ;

Ling, ZD ;

Pipeleers, D ;

Van de Casteele, M .

LIFE SCIENCES, 2005, 77 (11) :1273-1282

[26] Uncoupling protein 1 is necessary for norepinephrine-induced glucose utilization in brown adipose tissue [J].

Inokuma, K ;

Ogura-Kamatsu, Y ;

Toda, C ;

Kimura, K ;

Yamashita, H ;

Saito, M .

DIABETES, 2005, 54 (05) :1385-1391

[27] 5′-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4carboxamide riboside [J].

Jakobsen, SN ;

Hardie, DG ;

Morrice, N ;

Tornqvist, HE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (50) :46912-46916

[28] Integration of endocannabinoid and leptin signaling in an appetite-related neural circuit [J].

Jo, YH ;

Chen, YJJ ;

Chua, SC ;

Talmage, DA ;

Role, LW .

NEURON, 2005, 48 (06) :1055-1066

[29] AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism [J].

Kahn, BB ;

Alquier, T ;

Carling, D ;

Hardie, DG .

CELL METABOLISM, 2005, 1 (01) :15-25

[30] Metformin-induced stimulation of AMP-activated protein kinase in β-cells impairs their glucose responsiveness and can lead to apoptosis [J].

Kefas, BA ;

Cai, Y ;

Kerckhofs, K ;

Ling, ZD ;

Martens, G ;

Heimberg, H ;

Pipeleers, D ;

Van de Casteele, M .

BIOCHEMICAL PHARMACOLOGY, 2004, 68 (03) :409-416

← 1 2 3 4 5 6 7 8 9 →