Coexistence of familial antiphospholipid syndrome and factor V Leiden: Impact on thrombotic diathesis

被引：37

作者：

Brenner, B

Vulfsons, SL

Lanir, N

Nahir, M

机构：

[1] RAMBAM MED CTR,DEPT INTERNAL MED D,THROMBOSIS & HAEMOSTASIS UNIT,IL-31096 HAIFA,ISRAEL

[2] RAMBAM MED CTR,DEPT RHEUMATOL,IL-31096 HAIFA,ISRAEL

[3] TECHNION ISRAEL INST TECHNOL,BRUCE RAPPAPORT FAC MED,IL-31096 HAIFA,ISRAEL

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1996年 / 94卷 / 01期

关键词：

thrombosis; protein C resistance; antiphospholipid syndrome;

D O I：

10.1046/j.1365-2141.1996.d01-1757.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Two young siblings who presented with an unusual recurrent severe thromboembolic phenomenon were found to have familial anti-phospholipid syndrome and were heterozygous for the factor V R506Q mutation, The coexistence of hereditary and acquired APC-resistance may explain the severity of thrombo-embolism.

引用

收藏

页码：166 / 167

页数：2

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