Human umbilical cord mesenchymal stem cell-derived extracellular vesicles: A novel therapeutic paradigm

被引：194

作者：

Abbaszadeh, Hossein ^{[1
,2
]}

Ghorbani, Farzaneh ^{[1
,2
]}

Derakhshani, Mehdi ^{[2
]}

Movassaghpour, Aliakbar ^{[3
]}

Yousefi, Mehdi ^{[2
,4
]}

机构：

[1] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran

[2] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran

[3] Tabriz Univ Med Sci, Hematol & Oncol Res Ctr, Tabriz, Iran

[4] Tabriz Univ Med Sci, Sch Med, Dept Immunol, Tabriz, Iran

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2020年 / 235卷 / 02期

关键词：

exosomes; extracellular vesicles; hucMSCs; microvesicles; regenerative medicine; MYOFIBROBLAST DIFFERENTIATION; EXOSOMES; ANGIOGENESIS; INJURY; MICROVESICLES; EXPRESSION; RESPONSES; RECOVERY; PATHWAY; DISEASE;

D O I：

10.1002/jcp.29004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Mesenchymal stem cells (MSCs) have been revealed to hold great potential for the development of new treatment approaches for various diseases. However, the clinical use of these cells is limited due to their tumorigenic effects. The therapeutic benefits of MSCs are largely dependent on paracrine factors including extracellular vesicles (EVs). EVs are nano-sized bilayer membrane structures containing lipids, microRNAs and proteins which play key roles in cell-to-cell communications. Because of their lower immunogenicity, tumorigenicity, and easier management, EVs have emerged as a new promising alternative to whole-cell therapy. Therefore, this paper reviews current preclinical studies on the use of EVs derived from human umbilical cord MSCs (hucMSCs) as a therapeutic approach in treatment of several diseases including neurological, cardiovascular, liver, kidney, and bone diseases as well as the cutaneous wound, inflammatory bowel disease, cancers, infertility, and other disorders.

引用

页码：706 / 717

页数：12

共 85 条

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