The staphylococcal transferrin receptor: a glycolytic enzyme with novel functions

被引：78

作者：

Modun, B

Morrissey, J

Williams, P ^{[2
]}

机构：

[1] Univ Nottingham, Sch Pharmaceut Sci, Nottingham NG7 2RD, England

[2] Univ Nottingham, Queens Med Ctr, Inst Infect & Immun, Nottingham NG7 2UH, England

来源：

TRENDS IN MICROBIOLOGY | 2000年 / 8卷 / 05期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0966-842X(00)01728-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To obtain iron from the host for growth, staphylococci have evolved sophisticated iron-scavenging systems including siderophores and a cell surface receptor for transferrin, the mammalian iron-transporting glycoprotein. The staphylococcal transferrin receptor has been identified as a member of a newly emerging family of multifunctional, cell-surface-associated glyceraldehyde-3-phosphate dehydrogenases, which not only retain their glycolytic enzyme activities but also bind diverse human serum proteins and possess NAD-ribosylating activity. These multiple functions suggest a potential contribution to virulence far beyond iron acquisition.

引用

页码：231 / 237

页数：7

共 39 条

[1] RELATIVE AVAILABILITY OF TRANSFERRIN-BOUND IRON AND CELL-DERIVED IRON TO AEROBACTIN-PRODUCING AND ENTEROCHELIN-PRODUCING STRAINS OF ESCHERICHIA-COLI AND TO OTHER MICROORGANISMS [J].