Dynamic roles for G4 DNA in the biology of eukaryotic cells

被引：352

作者：

Maizels, Nancy

机构：

[1] Univ Washington, Sch Med, Dept Immunol, Seattle, WA 98195 USA

[2] Univ Washington, Sch Med, Dept Biochem, Seattle, WA 98195 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2006年 / 13卷 / 12期

关键词：

D O I：

10.1038/nsmb1171

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent advances have made a persuasive case for the existence of G4 DNA in living cells, but what-if any-are its functions? Experiments have established how G4 DNA may contribute to the biology of eukaryotic cells, and genomic analysis has identified new ways in which the potential to form G4 DNA may influence gene regulation and genomic stability. This Perspective highlights those advances and identifies some key open questions.

引用

收藏

页码：1055 / 1059

页数：5

相关论文

共 50 条

[1] Pot1, the putative telomere end-binding protein in fission yeast and humans [J].

Baumann, P ;

Cech, TR .

SCIENCE, 2001, 292 (5519) :1171-1175

[2] Essential role of limiting telomeres in the pathogenesis of Werner syndrome [J].

Chang, S ;

Multani, AS ;

Cabrera, NG ;

Naylor, ML ;

Laud, P ;

Lombard, D ;

Pathak, S ;

Guarente, L ;

DePinho, RA .

NATURE GENETICS, 2004, 36 (08) :877-882

[3]

Cheung I, 2002, NAT GENET, V31, P405, DOI [10.1038/417405a, 10.1038/ng928]

[4] Defective telomere lagging strand synthesis in cells lacking WRN helicase activity [J].

Crabbe, L ;

Verdun, RE ;

Haggblom, CI ;

Karlseder, J .

SCIENCE, 2004, 306 (5703) :1951-1953

[5] G4 DNA binding by LR1 and its subunits, nucleolin and hnRNP D, a role for G-G pairing in immunoglobulin switch recombination [J].

Dempsey, LA ;

Sun, H ;

Hanakahi, LA ;

Maizels, N .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (02) :1066-1071

[6] Regulation of murine telomere length by Rtel:: An essential gene encoding a helicase-like protein [J].

Ding, H ;

Schertzer, M ;

Wu, XL ;

Gertsenstein, M ;

Selig, S ;

Kammori, M ;

Pourvali, R ;

Poon, S ;

Vulto, I ;

Chavez, E ;

Tam, PPL ;

Nagy, A ;

Lansdorp, PM .

CELL, 2004, 117 (07) :873-886

[7] AID binds to transcription-induced structures in c-MYC that map to regions associated with translocation and hypermutation [J].

Duquette, ML ;

Pham, P ;

Goodman, MF ;

Maizels, N .

ONCOGENE, 2005, 24 (38) :5791-5798

[8] Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA [J].

Duquette, ML ;

Handa, P ;

Vincent, JA ;

Taylor, AF ;

Maizels, N .

GENES & DEVELOPMENT, 2004, 18 (13) :1618-1629

[9] Gene function correlates with potential for G4 DNA formation in the human genome [J].

Eddy, Johanna ;

Maizels, Nancy .

NUCLEIC ACIDS RESEARCH, 2006, 34 (14) :3887-3896

[10] Structure of hnRNP D complexed with single-stranded telomere DNA and unfolding of the quadruplex by heterogeneous nuclear ribonucleoprotein D [J].

Enokizono, Y ;

Konishi, Y ;

Nagata, K ;

Ouhashi, K ;

Uesugi, S ;

Ishikawa, F ;

Katahira, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (19) :18862-18870

← 1 2 3 4 5 →