High expressions of galectin-1 and VEGF are associated with poor prognosis in gastric cancer patients

被引：67

作者：

Chen, Jie ^{[2
,3
]}

Tang, Dong ^{[1
]}

Wang, Sen ^{[4
]}

Li, Qing-Guo ^{[1
]}

Zhang, Ji-Ran ^{[1
]}

Li, Ping ^{[1
]}

Lu, Qi ^{[1
]}

Niu, Gang ^{[1
]}

Gao, Jun ^{[1
]}

Ye, Nian-Yuan ^{[1
]}

Wang, Dao-Rong ^{[1
]}

机构：

[1] Yangzhou Univ, Dept Gastrointestinal Surg, Subei Peoples Hosp Jiangsu Prov, Clin Med Sch 1, Yangzhou 225001, Jiangsu, Peoples R China

[2] Fudan Univ, Shanghai Canc Ctr, Dept Gastr Canc & Soft Tissue Sarcomas, Shanghai 200032, Peoples R China

[3] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200032, Peoples R China

[4] Nanjing Med Univ, Basic Med Coll, Nanjing 210000, Jiangsu, Peoples R China

来源：

TUMOR BIOLOGY | 2014年 / 35卷 / 03期

关键词：

Galectin-1; VEGF; Gastric cancer; Prognosis; Survival; ENDOTHELIAL GROWTH-FACTOR; COLORECTAL-CANCER; CLINICAL-SIGNIFICANCE; TUMOR-GROWTH; CELLS; ANGIOGENESIS; PROGRESSION; METASTASIS; DENSITY; PATHWAY;

D O I：

10.1007/s13277-013-1332-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

High expressions of galectin-1 and vascular endothelial growth factor (VEGF) are correlated with biological behavior in some cancers. The aim of this study is to evaluate the expressions of galectin-1 and VEGF in gastric cancer and investigate their relationships with clinicopathological factors and prognostic significance. Immunohistochemical analyses for galectin-1 and VEGF expression were performed on 108 cases of gastric cancer. The relationship between the expression and staining intensity of galectin-1 and VEGF, clinicopathological variables, and survival rates was analyzed. Immunohistochemical staining demonstrated that 68 of 108 gastric cancer samples (63.0 %) were positive for galectin-1 and 62 out of 108 gastric cancer samples (57.4 %) were positive for VEGF. Galectin-1 expression was associated with tumor size, differentiation grade, TNM stage, lymph node metastases, and VEGF expression. VEGF expression was related to tumor size, TNM stage, and lymph node metastases. Kaplan-Meier survival analysis showed that high galectin-1 and VEGF expressions exhibited significant correlations with poor prognosis for gastric cancer patients. Multivariate analysis revealed that galectin-1 and VEGF expressions were independent prognostic parameters for the overall survival rate of gastric cancer patients. The results of the present study suggest that galectin-1 expression is positively associated with VEGF expression. Both galectin-1 and VEGF can serve as independent prognostic indicators of poor survival for gastric cancer.

引用

页码：2513 / 2519

页数：7

共 37 条

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