EphB receptors coordinate migrationand proliferation in the intestinal stem cell niche

被引：253

作者：

Holmberg, Johan ^{[1
]}

Genander, Maria

Halford, Michael M.

Anneren, Cecilia

Sondell, Mariann

Chumley, Michael J.

Silvany, Robert E.

Henkemeyer, Mark

Frisen, Jonas

机构：

[1] Karolinska Inst, Med Nobel Inst, Dept Cell & Mol Biol, SE-17177 Stockholm, Sweden

[2] Univ Texas, SW Med Ctr, Ctr Dev Biol, Dallas, TX 75390 USA

来源：

CELL | 2006年 / 125卷 / 06期

关键词：

D O I：

10.1016/j.cell.2006.04.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

More than 10(10) cells are generated every day in the human intestine. Wnt proteins are key regulators of proliferation and are known endogenous mitogens for intestinal progenitor cells. The positioning of cells within the stem cell niche in the intestinal epithelium is controlled by B subclass ephrins through their interaction with EphB receptors. We report that EphB receptors, in addition to directing cell migration, regulate proliferation in the intestine. EphB signaling promotes cell-cycle reentry of progenitor cells and accounts for approximately 50% of the mitogenic activity in the adult mouse small intestine and colon. These data establish EphB receptors as key coordinators of migration and proliferation in the intestinal stem cell niche.

引用

页码：1151 / 1163

页数：13

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