How cells activate ATR

被引：35

作者：

Kumagai, Akiko ^{[1
]}

Dunphy, William G. ^{[1
]}

机构：

[1] CALTECH, Div Biol 21676, Pasadena, CA 91125 USA

来源：

CELL CYCLE | 2006年 / 5卷 / 12期

关键词：

ATR; TopBP1; ATRIP; DNA replication checkpoint; DNA damage;

D O I：

10.4161/cc.5.12.2834

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

ATR is a critical upstream regulator of checkpoint responses to incompletely replicated and damaged DNA. However, it had not been understood how the kinase activity of ATR is switched on during checkpoint responses. TopBP1 and its homologs are necessary for both DNA replication and checkpoint control. A recent report from this laboratory demonstrated that TopBP1 functions as an activator of ATR. It had been known that TopBP1 accumulates at sites of replicative stress and DNA damage. Thus, interaction of ATR with a critical protein at stalled replication forks and sites of DNA damage triggers its activation. This finding helps to explain how aberrant DNA structures in the genome induce ATR-dependent signaling processes.

引用

收藏

页码：1265 / 1268

页数：4

相关论文

共 43 条

[1] Cell cycle checkpoint signaling through the ATM and ATR kinases [J].

Abraham, RT .

GENES & DEVELOPMENT, 2001, 15 (17) :2177-2196

[2] DPB11, WHICH INTERACTS WITH DNA-POLYMERASE II(EPSILON) IN SACCHAROMYCES-CEREVISIAE, HAS A DUAL ROLE IN S-PHASE PROGRESSION AND AT A CELL-CYCLE CHECKPOINT [J].

ARAKI, H ;

LEEM, SH ;

PHONGDARA, A ;

SUGINO, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (25) :11791-11795

[3] DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation [J].

Bakkenist, CJ ;

Kastan, MB .

NATURE, 2003, 421 (6922) :499-506

[4] Initiating cellular stress responses [J].

Bakkenist, CJ ;

Kastan, MB .

CELL, 2004, 118 (01) :9-17

[5] ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation [J].

Ball, HL ;

Myers, JS ;

Cortez, D .

MOLECULAR BIOLOGY OF THE CELL, 2005, 16 (05) :2372-2381

[6] Surveillance of different recombination defects in mouse spermatocytes yields distinct responses despite elimination at an identical developmental stage [J].

Barchi, M ;

Mahadevaiah, S ;

Di Giacomo, M ;

Baudat, F ;

de Rooij, DG ;

Burgoyne, PS ;

Jasin, M ;

Keeney, S .

MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (16) :7203-7215

[7] Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint [J].

Byun, TS ;

Pacek, M ;

Yee, MC ;

Walter, JC ;

Cimprich, KA .

GENES & DEVELOPMENT, 2005, 19 (09) :1040-1052

[8] The BRCT domain: Signaling with friends? [J].

Caldecott, KW .

SCIENCE, 2003, 302 (5645) :579-580

[9] ATR and ATRIP: Partners in checkpoint signaling [J].

Cortez, D ;

Guntuku, S ;

Qin, J ;

Elledge, SJ .

SCIENCE, 2001, 294 (5547) :1713-1716

[10] An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication [J].

Costanzo, V ;

Shechter, D ;

Lupardus, PJ ;

Cimprich, KA ;

Gottesman, M ;

Gautier, J .

MOLECULAR CELL, 2003, 11 (01) :203-213

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