HPV6b virus like particles are potent immunogens without adjuvant in man

被引：130

作者：

Zhang, LF

Zhou, J

Chen, S

Cai, LL

Bao, QY

Zheng, FY

Lu, JQ

Padmanabha, J

Hengst, K

Malcolm, K

Frazer, IH ^{[1
]}

机构：

[1] Univ Queensland, Princess Alexandra Hosp, Ctr Immunol & Canc Res, Brisbane, Qld 4102, Australia

[2] Wenzhou Med Coll, Dept Microbiol, Wenzhou 325003, Zhejiang, Peoples R China

[3] Wenzhou Med Coll, Dept Obstet Gynaecol, Wenzhou 325003, Zhejiang, Peoples R China

来源：

VACCINE | 2000年 / 18卷 / 11-12期

基金：

英国医学研究理事会;

关键词：

papillomavirus; vaccines; virus like particles;

D O I：

10.1016/S0264-410X(99)00351-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Subjects with genital warts were immunized three times or more with HPV6b VLPs without adjuvant. All immunized subjects had DTH to HPV6b L1 protein. Of 32 subjects, nine had HPV6b specific antibody prior to immunization and 22 acquired antibody with immunization. VLP specific antibody increased following a single immunization in 6 of 8 subjects with low level antibody at recruitment. Complete regression of genital warts was observed in 25 of 33 evaluable subjects over the 20-week observation period. We conclude that immunization with HPV6b L1 VLPs without adjuvant induces immunity to the L1 protein epitopes recognised during natural infection, and may accelerate regression of warts. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：1051 / 1058

页数：8

相关论文

共 44 条

[1]

Barrasso R., 1998, Journal of Obstetrics and Gynaecology (Abingdon), V18, pS70

[2] HPV infections and immunosuppression [J].

Bavinck, JNB ;

Berkhout, RJM .

CLINICS IN DERMATOLOGY, 1997, 15 (03) :427-437

[3]

Beutner Karl R., 1997, American Journal of Medicine, V102, P28

[4] Treatment of genital warts with an immune-response modifier (imiquimod) [J].

Beutner, KR ;

Spruance, SL ;

Hougham, AJ ;

Fox, TL ;

Owens, ML ;

Douglas, JM .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1998, 38 (02) :230-239

[5] Imiquimod, a patient-applied immune-response modifier for treatment of external genital warts [J].

Beutner, KR ;

Tyring, SK ;

Trofatter, KF ;

Douglas, JM ;

Spruance, S ;

Owens, ML ;

Fox, TL ;

Hougham, AJ ;

Schmitt, KA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (04) :789-794

[6] Recombinant human interferon-beta for condylomata acuminata: a randomized, double-blind, placebo-controlled study of intralesional therapy [J].

Bornstein, J ;

Pascal, B ;

Zarfati, D ;

Goldshmid, N ;

Abramovici, H .

INTERNATIONAL JOURNAL OF STD & AIDS, 1997, 8 (10) :614-621

[7] IMMUNIZATION WITH VIRUS-LIKE PARTICLES FROM COTTONTAIL RABBIT PAPILLOMAVIRUS (CRPV) CAN PROTECT AGAINST EXPERIMENTAL CRPV INFECTION [J].

BREITBURD, F ;

KIRNBAUER, R ;

HUBBERT, NL ;

NONNENMACHER, B ;

TRINDINHDESMARQUET, C ;

ORTH, G ;

SCHILLER, JT ;

LOWY, DR .

JOURNAL OF VIROLOGY, 1995, 69 (06) :3959-3963

[8] The natural history of human papillomavirus type 16 capsid antibodies among a cohort of university women [J].

Carter, JJ ;

Koutsky, LA ;

Wipf, GC ;

Christensen, ND ;

Lee, SK ;

Kuypers, J ;

Kiviat, N ;

Galloway, DA .

JOURNAL OF INFECTIOUS DISEASES, 1996, 174 (05) :927-936

[9] Immunization with viruslike particles induces long-term protection of rabbits against challenge with cottontail rabbit papillomavirus [J].

Christensen, ND ;

Reed, CA ;

Cladel, NM ;

Han, R ;

Kreider, JW .

JOURNAL OF VIROLOGY, 1996, 70 (02) :960-965

[10] HUMAN PAPILLOMAVIRUS TYPE-6 AND TYPE-11 HAVE ANTIGENICALLY DISTINCT STRONGLY IMMUNOGENIC CONFORMATIONALLY DEPENDENT NEUTRALIZING EPITOPES [J].

CHRISTENSEN, ND ;

KIRNBAUER, R ;

SCHILLER, JT ;

GHIM, SJ ;

SCHLEGEL, R ;

JENSON, AB ;

KREIDER, JW .

VIROLOGY, 1994, 205 (01) :329-335

← 1 2 3 4 5 →