General method for the synthesis of N-methyl amino acids and N-alkyl amino esters from O'Donnell's Schiff bases

被引：30

作者：

Chruma, JJ ^{[1
]}

Sames, D ^{[1
]}

Polt, R ^{[1
]}

机构：

[1] UNIV ARIZONA,DEPT CHEM,TUCSON,AZ 85721

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 29期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4039(97)01132-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-methyl amino acids, including L-abrine, and N-alkyl amino esters, were synthesized by reductive amination of O'Donnell's Schiff base amino esters with NaBH3CN and formaldehyde, or the appropriate aldehyde in CH3CN or THF in good to excellent yields, and with high purity. (C) 1997 Elsevier Science Ltd.

引用

页码：5085 / 5086

页数：2

共 21 条

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