Winged helix proteins

被引：494

作者：

Gajiwala, KS

Burley, SK

机构：

[1] Rockefeller Univ, Lab Mol Biophys, New York, NY 10021 USA

[2] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10021 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2000年 / 10卷 / 01期

关键词：

D O I：

10.1016/S0959-440X(99)00057-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The winged helix proteins constitute a subfamily within the large ensemble of helix-turn-helix proteins. Since the discovery of the winged helix/fork head motif in 1993, a large number of topologically related proteins with diverse biological functions have been characterized by X-ray crystallography and solution NMR spectroscopy. Recently, a winged helix transcription factor (RFX1) was shown to bind DNA using unprecedented interactions between one of its eponymous wings and the major groove. This surprising observation suggests that the winged helix proteins can be subdivided into at least two classes with radically different modes of DNA recognition.

引用

收藏

页码：110 / 116

页数：7

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