Neural correlates of the object-recall process in semantic memory

被引:74
作者
Assaf, Michal
Calhoun, Vince D.
Kuzu, Cheedern H.
Kraut, Michael A.
Rivkin, Paul R.
Hart, John, Jr.
Pearlson, Godfrey D.
机构
[1] Olin Neuropsychiat Res Ctr, Inst Living, Hartford, CT 06106 USA
[2] Yale Univ, Dept Psychiat, New Haven, CT 06520 USA
[3] Johns Hopkins Univ, Dept Psychiat, Baltimore, MD 21205 USA
[4] Johns Hopkins Univ, Dept Radiol, Baltimore, MD 21205 USA
[5] Univ Arkansas Med Sci, GRECC, CAVHS, Dept Geriatr Neurol & Radiol, Little Rock, AR 72205 USA
关键词
fMRI; thalamus; anterior cingulate cortex; language; neuromiaging;
D O I
10.1016/j.pscychresns.2006.01.002
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The recall of an object from features is a specific operation in semantic memory in which the thalamus and pre-supplementary motor area (pre-SMA) are integrally involved. Other higher-order semantic cortices are also likely to be involved. We used the object-recall-from-features paradigm, with more sensitive scanning techniques and larger sample size, to replicate and extend our previous results. Eighteen right-handed healthy participants performed an object-recall task and an association semantic task, while undergoing functional magnetic resonance imaging. During object-recall, subjects determined whether words pairs describing object features combined to recall an object; during the association task they decided if two words were related. Of brain areas specifically involved in object recall, in addition to the thalamus and pre-SMA, other regions included the left dorsolateral prefrontal cortex, inferior parietal lobule, and middle temporal gyrus, and bilateral rostral anterior cingulate and inferior frontal gyri. These regions are involved in semantic processing, verbal working memory and response-conflict detection and monitoring. The thalamus likely helps to coordinate activity of these different brain areas. Understanding the circuit that normally mediates this process is relevant for schizophrenia, where many regions in this circuit are functionally abnormal and semantic memory is impaired. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:115 / 126
页数:12
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