Coat proteins and vesicle budding

被引:810
作者
Schekman, R
Orci, L
机构
[1] UNIV CALIF BERKELEY, HOWARD HUGHES MED INST, BERKELEY, CA 94720 USA
[2] UNIV GENEVA, FAC MED, DEPT MORPHOL, CH-1211 GENEVA 4, SWITZERLAND
关键词
D O I
10.1126/science.271.5255.1526
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The trafficking of proteins within eukaryotic cells is achieved by the capture of cargo and targeting molecules into vesicles that bud from a donor membrane and deliver their contents to a receiving compartment. This process is bidirectional and may involve multiple organelles within a cell. Distinct coat proteins mediate each budding event, serving both to shape the transport vesicle and to select by direct or indirect interaction the desired set of cargo molecules. Secretion, which has been viewed as a default pathway, may require sorting and packaging signals on transported molecules to ensure their rapid delivery to the cell surface.
引用
收藏
页码:1526 / 1533
页数:8
相关论文
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