Synthesis of 2-aryltryptamines with palladium catalyzed cross-coupling of 2-bromotryptamines and arylboronic acids

被引：40

作者：

Chu, L

Fisher, MH

Goulet, MT

Wyvratt, MJ

机构：

[1] Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 22期

关键词：

D O I：

10.1016/S0040-4039(97)00797-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A versatile and high-yielding synthesis of 2-aryltryptamines employing palladium(0) catalysed cross-coupling of 2-bromotryptamines and arylboronic acids was developed. The preparation of the intermediate 2-bromotryptamines with pyridine hydrobromide perbromide as the brominating agent, is also reported. (C) 1997 Elsevier Science Ltd.

引用

页码：3871 / 3874

页数：4

共 19 条

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