Novel intramolecular radical Ar-C glycosylation-lactonization reaction in the transformation of capuramycin

被引：1

作者：

Hotoda, H

Daigo, M

Takatsu, T

Muramatsu, A

Kaneko, M

机构：

[1] Sankyo Co Ltd, Exploratory Chem Res Labs, Shinagawa Ku, Tokyo 1408710, Japan

[2] Sankyo Co Ltd, Biomed Res Labs, Shinagawa Ku, Tokyo 1408710, Japan

来源：

HETEROCYCLES | 2000年 / 52卷 / 01期

关键词：

D O I：

10.3987/COM-99-S46

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Radical deoxygenation of capuramycin derivative (2a,b) gave the unexpected lactone (3a,b) in moderate yield via a novel intramolecular radical Ar-C glycosylation-lactonization reaction. R-115381 and R-116022, thus obtained, showed weak antimicrobial activity against several Gram-positive bacteria.

引用

页码：133 / 136

页数：4

共 4 条

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