Metabolic substrates of neuronal aging

被引：8

作者：

Toescu, EC ^{[1
]}

Xiong, J ^{[1
]}

机构：

[1] Univ Birmingham, Dept Physiol, Birmingham B15 2TT, W Midlands, England

来源：

STRATEGIES FOR ENGINEERED NEGLIGIBLE SENESCENCE: WHY GENUINE CONTROL OF AGING MAY BE FORESEEABLE | 2004年 / 1019卷

关键词：

aging; brain; Ca2+1](i); cerebellar granule; homeostasis; neuron;

D O I：

10.1196/annals.1297.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

One mechanism proposed to explain age-dependent changes has been the "Ca2+ hypothesis" of aging. Data indicate that most changes in the Ca2+ homeostasis of the cerebellar granule neurons appear only when the aged neurons are exposed to higher levels of stimulation and that these changes are secondary to metabolic limitations imposed by altered mitochondrial function.

引用

页码：19 / 23

页数：5

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