Synthesis and immunosuppressive activity of new artemisinin derivatives.: Part 2:: 2-[12(β or α)-dihydroartemisinoxymethyl-(or 1′-ethyl)]phenoxyl propionic acids and esters

被引：28

作者：

Yang, Zhong-Shun

Wang, Jun-Xia

Zhou, Yu

Zuo, Han-Ping

Li, Ying ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res,Dept Pharmacol 1, Shanghai 201203, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Dept Synthet Chem, Shanghai 201203, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 23期

关键词：

Artemisinin derivatives; Immunosuppressive activity; Inhibitory effect; Synthesis;

D O I：

10.1016/j.bmc.2006.07.038

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Another series of novel dihydroartemisinin derivatives were synthesized and assessed for their cytotoxicity of lymphocyte, inhibitory activity on mitogen-induced spleen lymphocyte proliferation in vitro. Some of the compounds exhibited inhibitory effects on ConA-induced T cell and LPS-induced B cell proliferation comparable to or more potent than parent artemisinin. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：8043 / 8049

页数：7

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