Ginkgo biloba inhibits hydrogen peroxide-induced activation of nuclear factor kappa B in vascular endothelial cells

被引：31

作者：

Wei, ZH ^{[1
]}

Peng, QL ^{[1
]}

Lau, BHS ^{[1
]}

Shah, V ^{[1
]}

机构：

[1] Loma Linda Univ, Sch Med, Dept Microbiol & Mol Genet, Loma Linda, CA 92350 USA

来源：

GENERAL PHARMACOLOGY | 1999年 / 33卷 / 05期

关键词：

Ginkgo biloba; hydrogen peroxide; nuclear factor kappa B; vascular endothelial cells;

D O I：

10.1016/S0306-3623(99)00027-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present study determined the effects of Ginkgo biloba extract (GBE) on the activation of nuclear factor kappa B (NF-kappa B) and the level of hydrogen peroxide (H2O2) in bovine pulmonary artery endothelial cells (PAEC). H2O2 showed a concentration-dependent activation of NF-kappa B. GEE demonstrated a concentration-dependent suppression of NF-kappa B activated by H2O2. GEE directly scavenged H2O2 in a cell-free system; it also decreased H2O2 levels in PAEC. These results suggest that the inhibitory effect of GEE on H2O2-induced NF-kappa B activation may be caused by its scavenging and suppression of H2O2. Our experiments demonstrate that GEE can inhibit NF-kappa B activation induced by H2O2 and may thus be effective for the prevention or treatment of atherosclerosis and other disorders related to NF-kappa B activation. (C) 1999 Elsevier Science Inc. All rights reserved.

引用

页码：369 / 375

页数：7

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