Interaction between gastric cancer stem cells and the tumor microenvironment

被引：55

作者：

Ishimoto, Takatsugu ^{[1
]}

Sawayama, Hiroshi ^{[1
]}

Sugihara, Hidetaka ^{[1
]}

Baba, Hideo ^{[1
]}

机构：

[1] Kumamoto Univ, Grad Sch Med Sci, Dept Surg Gastroenterol, Kumamoto 8608556, Japan

来源：

JOURNAL OF GASTROENTEROLOGY | 2014年 / 49卷 / 07期

关键词：

Cancer stem cell; Tumor microenvironment; Niche; Gastric cancer; VASCULOGENIC MIMICRY; SELF-RENEWAL; ACTIVATED MACROPHAGES; PROMOTE ANGIOGENESIS; MULTIDRUG-RESISTANCE; COLORECTAL-CANCER; PROSTAGLANDIN E-2; MELANOMA-CELLS; IN-VIVO; WNT;

D O I：

10.1007/s00535-014-0952-0

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Gastric cancer (GC) remains a leading cause of cancer-related deaths worldwide. Cancer stem cells (CSCs) are selectively capable of tumor initiation and are implicated in tumor relapse and metastasis, thus, governing the prognosis of GC patients. Stromal cells and extracellular matrix adjacent to cancer cells are known to form a supportive environment for cancer progression. CSC properties are also regulated by their microenvironment through cell signaling and related factors. This review presents the current findings regarding the influence of the tumor microenvironment on GC stem cells, which will support the development of novel therapeutic strategies for patients with GC.

引用

页码：1111 / 1120

页数：10

共 118 条

[1]

Prospective identification of tumorigenic breast cancer cells [J].

Al-Hajj, M ;

Wicha, MS ;

Benito-Hernandez, A ;

Morrison, SJ ;

Clarke, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988

[2]

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell [J].

Bonnet, D ;

Dick, JE .

NATURE MEDICINE, 1997, 3 (07) :730-737

[3]

Boral Debasish, 2012, Front Biosci (Elite Ed), V4, P2502

[4]

Cancer Stem Cell Niche: The Place to Be [J].

Borovski, Tijana ;

Melo, Felipe De Sousa E. ;

Vermeulen, Louis ;

Medema, Jan Paul .

CANCER RESEARCH, 2011, 71 (03) :634-639

[5]

Hematopoietic stem cell fate is established by the Notch-Runx pathway [J].

Burns, CE ;

Traver, D ;

Mayhall, E ;

Shepard, JL ;

Zon, LI .

GENES & DEVELOPMENT, 2005, 19 (19) :2331-2342

[6]

The Wnt/β-catenin pathway regulates self-renewal of cancer stem-like cells in human gastric cancer [J].

Cai, Chen ;

Zhu, Xiaohan .

MOLECULAR MEDICINE REPORTS, 2012, 5 (05) :1191-1196

[7]

A perivascular niche for brain tumor stem cells [J].

Calabrese, Christopher ;

Poppleton, Helen ;

Kocak, Mehmet ;

Hogg, Twala L. ;

Fuller, Christine ;

Hamner, Blair ;

Oh, Eun Young ;

Gaber, M. Waleed ;

Finklestein, David ;

Allen, Meredith ;

Frank, Adrian ;

Bayazitov, Ildar T. ;

Zakharenko, Stanislav S. ;

Gajjar, Amar ;

Davidoff, Andrew ;

Gilbertson, Richard J. .

CANCER CELL, 2007, 11 (01) :69-82

[8]

Tumour vasculogenic mimicry is associated with poor prognosis of human cancer patients: A systemic review and meta-analysis [J].

Cao, Zhifei ;

Bao, Meimei ;

Miele, Lucio ;

Sarkar, Fazlul H. ;

Wang, Zhiwei ;

Zhou, Quansheng .

EUROPEAN JOURNAL OF CANCER, 2013, 49 (18) :3914-3923

[9]

Identification and expansion of cancer stem cells in tumor tissues and peripheral blood derived from gastric adenocarcinoma patients [J].

Chen, Tie ;

Yang, Kun ;

Yu, Jianhua ;

Meng, Wentong ;

Yuan, Dandan ;

Bi, Feng ;

Liu, Fang ;

Liu, Jie ;

Dai, Bing ;

Chen, Xinzu ;

Wang, Fang ;

Zeng, Fan ;

Xu, Hong ;

Hu, Jiankun ;

Mo, Xianming .

CELL RESEARCH, 2012, 22 (01) :248-258

[10]

Stem cells and cancer: Two faces of eve [J].

Clarke, MF ;

Fuller, M .

CELL, 2006, 124 (06) :1111-1115

← 1 2 3 4 5 6 7 8 9 10 →