Estrogenic activity of pharmaceuticals in the aquatic environment

被引：62

作者：

Isidori, Marina ^{[1
]}

Bellotta, Maria ^{[1
]}

Cangiano, Margherita ^{[1
]}

Parrella, Alfredo ^{[1
]}

机构：

[1] Univ Naples 2, Dipartimento Sci Vita, IC REACH, I-81100 Caserta, Italy

来源：

ENVIRONMENT INTERNATIONAL | 2009年 / 35卷 / 05期

关键词：

Pharmaceuticals; Endocrine interference; YES-test; E-screen; PERSONAL CARE PRODUCTS; E-SCREEN ASSAY; ENDOCRINE DISRUPTION; STW EFFLUENT; IDENTIFICATION; CHEMICALS; TOXICITY; PHOTODEGRADATION; DERIVATIVES; ORGANISMS;

D O I：

10.1016/j.envint.2008.11.006

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

In the last years pharmaceuticals have aroused great interest as environmental pollutants for their toxic effects towards non target organisms. This study wants to draw attention to a further adverse effect of drugs, the endocrine interference. The most representative drugs of the widespread classes in environment were investigated. The YES-test and the E-screen assay were performed to detect the capability of these substances to bind the human estrogenic receptor alpha (hER alpha) in comparison with 17 beta-estradiol. Out of 14 tested pharmaceuticals, 9 were positive to YES-assay and 11 were positive to E-screen assay; in particular, Furosemide and the fibrates (Bezafibrate, Fenofibrate and Gemfibrozil) gave the maximal estrogenic response. Tamoxifen showed its dual activity as agonist and antagonist of hER alpha. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：826 / 829

页数：4

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