A Long Noncoding RNA Activated by TGF-β Promotes the Invasion-Metastasis Cascade in Hepatocellular Carcinoma

被引：1531

作者：

Yuan, Ji-hang ^{[1
]}

Yang, Fu ^{[1
]}

Wang, Fang ^{[1
]}

Ma, Jin-zhao ^{[1
]}

Guo, Ying-jun ^{[1
]}

Tao, Qi-fei ^{[2
]}

Liu, Feng ^{[1
]}

Pan, Wei ^{[1
]}

Wang, Tian-tian ^{[1
]}

Zhou, Chuan-chuan ^{[1
]}

Wang, Shao-bing ^{[1
]}

Wang, Yu-zhao ^{[1
]}

Yang, Yuan ^{[2
]}

Yang, Ning ^{[3
]}

Zhou, Wei-ping ^{[2
]}

Yang, Guang-shun ^{[3
]}

Sun, Shu-han ^{[1
]}

机构：

[1] Second Mil Med Univ, Dept Med Genet, Shanghai 200433, Peoples R China

[2] Second Mil Med Univ, Eastern Hepatobiliary Hosp, Dept Hepat Surg 3, Shanghai 200433, Peoples R China

[3] Second Mil Med Univ, Eastern Hepatobiliary Hosp, Dept Hepat Surg 5, Shanghai 200433, Peoples R China

来源：

CANCER CELL | 2014年 / 25卷 / 05期

基金：

上海市自然科学基金; 中国国家自然科学基金;

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; GROWTH-FACTOR-BETA; VENOUS METASTASES; CANCER METASTASIS; TUMOR-SUPPRESSOR; MIR-200; FAMILY; REPRESSION; CELLS; TUMORIGENESIS; EXPRESSION;

D O I：

10.1016/j.ccr.2014.03.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The role of TGF-beta-induced epithelial-mesenchymal transition (EMT) in cancer cell dissemination is well established, but the involvement of lncRNAs in TGF-beta signaling is still unknown. In this study, we observed that the lncRNA-activated by TGF-beta (lncRNA-ATB) was upregulated in hepatocellular carcinoma (HCC) metastases and associated with poor prognosis. lncRNA-ATB upregulated ZEB1 and ZEB2 by competitively binding the miR-200 family and then induced EMT and invasion. In addition, lncRNA-ATB promoted organ colonization of disseminated tumor cells by binding IL-11 mRNA, autocrine induction of IL-11, and triggering STAT3 signaling. Globally, lncRNA-ATB promotes the invasion-metastasis cascade. Thus, these findings suggest that lncRNA-ATB, a mediator of TGF-beta signaling, could predispose HCC patients to metastases and may serve as a potential target for antimetastatic therapies.

引用

页码：666 / 681

页数：16

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