共 37 条
PICOT inhibits cardiac hypertrophy and enhances ventricular function and cardiomyocyte contractility
被引:74
作者:

Jeong, Dongtak
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机构: Gwangju Inst Sci & Technol, Dept Life Sci, Kwangju 500712, South Korea

Cha, Hyeseon
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机构: Gwangju Inst Sci & Technol, Dept Life Sci, Kwangju 500712, South Korea

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Kang, Misuk
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机构: Gwangju Inst Sci & Technol, Dept Life Sci, Kwangju 500712, South Korea

Yang, Dong Kwon
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h-index: 0
机构: Gwangju Inst Sci & Technol, Dept Life Sci, Kwangju 500712, South Korea

Kim, Ji Myoung
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h-index: 0
机构: Gwangju Inst Sci & Technol, Dept Life Sci, Kwangju 500712, South Korea

Yoon, Pyoung Oh
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机构: Gwangju Inst Sci & Technol, Dept Life Sci, Kwangju 500712, South Korea

Oh, Jae Gyun
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机构: Gwangju Inst Sci & Technol, Dept Life Sci, Kwangju 500712, South Korea

Bernecker, Oliver Y.
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机构: Gwangju Inst Sci & Technol, Dept Life Sci, Kwangju 500712, South Korea

Sakata, Susumu
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机构: Gwangju Inst Sci & Technol, Dept Life Sci, Kwangju 500712, South Korea

Thu, Le Thi
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机构: Gwangju Inst Sci & Technol, Dept Life Sci, Kwangju 500712, South Korea

Cui, Lei
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机构: Gwangju Inst Sci & Technol, Dept Life Sci, Kwangju 500712, South Korea

Lee, Young-Hoon
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机构: Gwangju Inst Sci & Technol, Dept Life Sci, Kwangju 500712, South Korea

Kim, Do Han
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机构: Gwangju Inst Sci & Technol, Dept Life Sci, Kwangju 500712, South Korea

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Liao, Ronglih
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机构: Gwangju Inst Sci & Technol, Dept Life Sci, Kwangju 500712, South Korea

Hajjar, Roger J.
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h-index: 0
机构: Gwangju Inst Sci & Technol, Dept Life Sci, Kwangju 500712, South Korea

Park, Woo Jin
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机构: Gwangju Inst Sci & Technol, Dept Life Sci, Kwangju 500712, South Korea
机构:
[1] Gwangju Inst Sci & Technol, Dept Life Sci, Kwangju 500712, South Korea
[2] Gwangju Inst Sci & Technol, Global Res Lab Cardiovasc Gene Therapy, Kwangju 500712, South Korea
[3] Massachusetts Gen Hosp, Cardiovasc Res Ctr, Charlestown, MA USA
[4] Harvard Univ, Sch Med, Charlestown, MA USA
[5] Chungnam Natl Univ, Coll Pharm, Taejon, South Korea
[6] Brigham & Womens Hosp, Div Cardiovasc, Boston, MA 02115 USA
[7] Harvard Univ, Sch Med, Boston, MA 02115 USA
[8] Chonbuk Natl Univ, Sch Dent, Dept Oral Anat, Jeonju, South Korea
关键词:
cardiac hypertrophy;
protein kinase C;
PICOT;
contractility;
D O I:
10.1161/01.RES.0000234780.06115.2c
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Multiple signaling pathways involving protein kinase C (PKC) have been implicated in the development of cardiac hypertrophy. We observed that a putative PKC inhibitor, PICOT ((P) under bar KC-(I) under bar nteracting (C) under bar ousin (O) under barf (T) under bar hioredoxin) was upregulated in response to hypertrophic stimuli both in vitro and in vivo. This suggested that PICOT may act as an endogenous negative feedback regulator of cardiac hypertrophy through its ability to inhibit PKC activity, which is elevated during cardiac hypertrophy. Adenovirus-mediated gene transfer of PICOT completely blocked the hypertrophic response of neonatal rat cardiomyocytes to enthothelin-1 and phenylephrine, as demonstrated by cell size, sarcomere rearrangement, atrial natriuretic factor expression, and rates of protein synthesis. Transgenic mice with cardiac-specific overexpression of PICOT showed that PICOT is a potent inhibitor of cardiac hypertrophy induced by pressure overload. In addition, PICOT overexpression dramatically increased the ventricular function and cardiomyocyte contractility as measured by ejection fraction and end-systolic pressure of transgenic hearts and peak shortening of isolated cardiomyocytes, respectively. Intracellular Ca2+ handing analysis revealed that increases in myofilament Ca2+ responsiveness, together with increased rate of sarcoplasmic reticulum Ca2+ reuptake, are associated with the enhanced contractility in PICOT-overexpressing cardiomyocytes. The inhibition of cardiac remodeling by of PICOT with a concomitant increase in ventricular function and cardiomyocyte contractility suggests that PICOT may provide an efficient modality for treatment of cardiac hypertrophy and heart failure.
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页码:307 / 314
页数:8
相关论文
共 37 条
[1]
CHARACTERIZATION OF PROTEIN-KINASE-C ISOTYPE EXPRESSION IN ADULT-RAT HEART - PROTEIN-KINASE C-EPSILON IS A MAJOR ISOTYPE PRESENT, AND IT IS ACTIVATED BY PHORBOL ESTERS, EPINEPHRINE, AND ENDOTHELIN
[J].
BOGOYEVITCH, MA
;
PARKER, PJ
;
SUGDEN, PH
.
CIRCULATION RESEARCH,
1993, 72 (04)
:757-767

BOGOYEVITCH, MA
论文数: 0 引用数: 0
h-index: 0
机构: NATL HEART & LUNG INST, DEPT CARDIAC MED, DOVEHOUSE ST, LONDON SW3 6LY, ENGLAND

PARKER, PJ
论文数: 0 引用数: 0
h-index: 0
机构: NATL HEART & LUNG INST, DEPT CARDIAC MED, DOVEHOUSE ST, LONDON SW3 6LY, ENGLAND

SUGDEN, PH
论文数: 0 引用数: 0
h-index: 0
机构: NATL HEART & LUNG INST, DEPT CARDIAC MED, DOVEHOUSE ST, LONDON SW3 6LY, ENGLAND
[2]
Differential regulation of cardiac protein kinase C isozyme expression after aortic banding in rat
[J].
Braun, MU
;
LaRosée, P
;
Schön, S
;
Borst, MM
;
Strasser, RH
.
CARDIOVASCULAR RESEARCH,
2002, 56 (01)
:52-63

Braun, MU
论文数: 0 引用数: 0
h-index: 0
机构: Tech Univ Dresden, Med Clin 2, Dept Cardiol, D-01307 Dresden, Germany

LaRosée, P
论文数: 0 引用数: 0
h-index: 0
机构: Tech Univ Dresden, Med Clin 2, Dept Cardiol, D-01307 Dresden, Germany

Schön, S
论文数: 0 引用数: 0
h-index: 0
机构: Tech Univ Dresden, Med Clin 2, Dept Cardiol, D-01307 Dresden, Germany

Borst, MM
论文数: 0 引用数: 0
h-index: 0
机构: Tech Univ Dresden, Med Clin 2, Dept Cardiol, D-01307 Dresden, Germany

Strasser, RH
论文数: 0 引用数: 0
h-index: 0
机构: Tech Univ Dresden, Med Clin 2, Dept Cardiol, D-01307 Dresden, Germany
[3]
PKC-α regulates cardiac contractility and propensity toward heart failure
[J].
Braz, JC
;
Gregory, K
;
Pathak, A
;
Zhao, W
;
Sahin, B
;
Klevitsky, R
;
Kimball, TF
;
Lorenz, JN
;
Nairn, AC
;
Liggett, SB
;
Bodi, I
;
Wang, S
;
Schwartz, A
;
Lakatta, EG
;
DePaoli-Roach, AA
;
Robbins, J
;
Hewett, TE
;
Bibb, JA
;
Westfall, MV
;
Kranias, EG
;
Molkentin, JD
.
NATURE MEDICINE,
2004, 10 (03)
:248-254

Braz, JC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA

Gregory, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA

Pathak, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA

Zhao, W
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA

Sahin, B
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA

Klevitsky, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA

Kimball, TF
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA

Lorenz, JN
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA

Nairn, AC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA

Liggett, SB
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA

Bodi, I
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA

Wang, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA

Schwartz, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA

Lakatta, EG
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA

DePaoli-Roach, AA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA

Robbins, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA

Hewett, TE
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA

Bibb, JA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA

Westfall, MV
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA

Kranias, EG
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA

Molkentin, JD
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA
[4]
Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NEAT signaling
[J].
Braz, JC
;
Bueno, OF
;
Liang, QR
;
Wilkins, BJ
;
Dai, YS
;
Parsons, S
;
Braunwart, J
;
Glascock, BJ
;
Klevitsky, R
;
Kimball, TF
;
Hewett, TE
;
Molkentin, JD
.
JOURNAL OF CLINICAL INVESTIGATION,
2003, 111 (10)
:1475-1486

Braz, JC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Dept Pediat, Med Ctr,Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA

Bueno, OF
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Dept Pediat, Med Ctr,Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA

Liang, QR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Dept Pediat, Med Ctr,Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA

Wilkins, BJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Dept Pediat, Med Ctr,Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA

Dai, YS
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Dept Pediat, Med Ctr,Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA

Parsons, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Dept Pediat, Med Ctr,Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA

Braunwart, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Dept Pediat, Med Ctr,Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA

Glascock, BJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Dept Pediat, Med Ctr,Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA

Klevitsky, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Dept Pediat, Med Ctr,Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA

Kimball, TF
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Dept Pediat, Med Ctr,Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA

Hewett, TE
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Dept Pediat, Med Ctr,Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA

Molkentin, JD
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Dept Pediat, Med Ctr,Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA
[5]
PKCα regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase1/2 (ERK1/2)
[J].
Braz, JC
;
Bueno, OF
;
De Windt, LJ
;
Molkentin, JD
.
JOURNAL OF CELL BIOLOGY,
2002, 156 (05)
:905-919

Braz, JC
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat,Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat,Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA

Bueno, OF
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat,Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat,Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA

De Windt, LJ
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat,Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat,Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA

Molkentin, JD
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat,Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat,Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA
[6]
The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice
[J].
Bueno, OF
;
De Windt, LJ
;
Tymitz, KM
;
Witt, SA
;
Kimball, TR
;
Klevitsky, R
;
Hewett, TE
;
Jones, SP
;
Lefer, DJ
;
Peng, CF
;
Kitsis, RN
;
Molkentin, JD
.
EMBO JOURNAL,
2000, 19 (23)
:6341-6350

Bueno, OF
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat,Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA

De Windt, LJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat,Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA

Tymitz, KM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat,Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA

Witt, SA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat,Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA

Kimball, TR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat,Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA

Klevitsky, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat,Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA

Hewett, TE
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat,Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA

Jones, SP
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat,Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA

Lefer, DJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat,Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA

Peng, CF
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat,Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA

Kitsis, RN
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat,Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA

Molkentin, JD
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat,Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA
[7]
The transcriptional repressor Nab1 is a specific regulator of pathological cardiac hypertrophy
[J].
Buitrago, M
;
Lorenz, K
;
Maass, AH
;
Maass, SO
;
Keller, U
;
Schmitteckert, EM
;
Ivashchenko, Y
;
Lohse, MJ
;
Engelhardt, S
.
NATURE MEDICINE,
2005, 11 (08)
:837-844

Buitrago, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wurzburg, Rudolf Virchow Ctr, DFG, Res Ctr Expt Biomed, D-97078 Wurzburg, Germany

Lorenz, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wurzburg, Rudolf Virchow Ctr, DFG, Res Ctr Expt Biomed, D-97078 Wurzburg, Germany

Maass, AH
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wurzburg, Rudolf Virchow Ctr, DFG, Res Ctr Expt Biomed, D-97078 Wurzburg, Germany

Maass, SO
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wurzburg, Rudolf Virchow Ctr, DFG, Res Ctr Expt Biomed, D-97078 Wurzburg, Germany

Keller, U
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wurzburg, Rudolf Virchow Ctr, DFG, Res Ctr Expt Biomed, D-97078 Wurzburg, Germany

Schmitteckert, EM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wurzburg, Rudolf Virchow Ctr, DFG, Res Ctr Expt Biomed, D-97078 Wurzburg, Germany

Ivashchenko, Y
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wurzburg, Rudolf Virchow Ctr, DFG, Res Ctr Expt Biomed, D-97078 Wurzburg, Germany

Lohse, MJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wurzburg, Rudolf Virchow Ctr, DFG, Res Ctr Expt Biomed, D-97078 Wurzburg, Germany

Engelhardt, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wurzburg, Rudolf Virchow Ctr, DFG, Res Ctr Expt Biomed, D-97078 Wurzburg, Germany
[8]
LOCALIZATION OF PROTEIN-KINASE-C ISOZYMES IN CARDIAC MYOCYTES
[J].
DISATNIK, MH
;
BURAGGI, G
;
MOCHLYROSEN, D
.
EXPERIMENTAL CELL RESEARCH,
1994, 210 (02)
:287-297

DISATNIK, MH
论文数: 0 引用数: 0
h-index: 0
机构:
STANFORD UNIV,SCH MED,DEPT MOLEC PHARMACOL,STANFORD,CA 94305 STANFORD UNIV,SCH MED,DEPT MOLEC PHARMACOL,STANFORD,CA 94305

BURAGGI, G
论文数: 0 引用数: 0
h-index: 0
机构:
STANFORD UNIV,SCH MED,DEPT MOLEC PHARMACOL,STANFORD,CA 94305 STANFORD UNIV,SCH MED,DEPT MOLEC PHARMACOL,STANFORD,CA 94305

MOCHLYROSEN, D
论文数: 0 引用数: 0
h-index: 0
机构:
STANFORD UNIV,SCH MED,DEPT MOLEC PHARMACOL,STANFORD,CA 94305 STANFORD UNIV,SCH MED,DEPT MOLEC PHARMACOL,STANFORD,CA 94305
[9]
Cardiac hypertrophy: The good, the bad and the ugly
[J].
Frey, N
;
Olson, EN
.
ANNUAL REVIEW OF PHYSIOLOGY,
2003, 65
:45-79

Frey, N
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA

Olson, EN
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA
[10]
Mutations in the human muscle LIM protein gene in families with hypertrophic cardiomyopathy
[J].
Geier, C
;
Perrot, A
;
Özcelik, C
;
Binner, P
;
Counsell, D
;
Hoffmann, K
;
Pilz, B
;
Martiniak, Y
;
Gehmlich, KA
;
van der Ven, PFM
;
Fürst, DO
;
Vornwald, A
;
von Hodenberg, E
;
Nürnberg, P
;
Scheffold, T
;
Dietz, R
;
Osterziel, KJ
.
CIRCULATION,
2003, 107 (10)
:1390-1395

Geier, C
论文数: 0 引用数: 0
h-index: 0
机构: Humboldt Univ, Franz Volhard Klin, D-13125 Berlin, Germany

Perrot, A
论文数: 0 引用数: 0
h-index: 0
机构: Humboldt Univ, Franz Volhard Klin, D-13125 Berlin, Germany

Özcelik, C
论文数: 0 引用数: 0
h-index: 0
机构: Humboldt Univ, Franz Volhard Klin, D-13125 Berlin, Germany

Binner, P
论文数: 0 引用数: 0
h-index: 0
机构: Humboldt Univ, Franz Volhard Klin, D-13125 Berlin, Germany

Counsell, D
论文数: 0 引用数: 0
h-index: 0
机构: Humboldt Univ, Franz Volhard Klin, D-13125 Berlin, Germany

Hoffmann, K
论文数: 0 引用数: 0
h-index: 0
机构: Humboldt Univ, Franz Volhard Klin, D-13125 Berlin, Germany

Pilz, B
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机构: Humboldt Univ, Franz Volhard Klin, D-13125 Berlin, Germany

Martiniak, Y
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机构: Humboldt Univ, Franz Volhard Klin, D-13125 Berlin, Germany

Gehmlich, KA
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机构: Humboldt Univ, Franz Volhard Klin, D-13125 Berlin, Germany

van der Ven, PFM
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机构: Humboldt Univ, Franz Volhard Klin, D-13125 Berlin, Germany

Fürst, DO
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机构: Humboldt Univ, Franz Volhard Klin, D-13125 Berlin, Germany

Vornwald, A
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机构: Humboldt Univ, Franz Volhard Klin, D-13125 Berlin, Germany

von Hodenberg, E
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机构: Humboldt Univ, Franz Volhard Klin, D-13125 Berlin, Germany

Nürnberg, P
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Scheffold, T
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机构: Humboldt Univ, Franz Volhard Klin, D-13125 Berlin, Germany

Dietz, R
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机构: Humboldt Univ, Franz Volhard Klin, D-13125 Berlin, Germany

Osterziel, KJ
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机构: Humboldt Univ, Franz Volhard Klin, D-13125 Berlin, Germany