Testosterone inhibits tumor necrosis factor-α-induced vascular cell adhesion molecule-1 expression in human aortic endothelial cells

被引：89

作者：

Hatakeyama, H ^{[1
]}

Nishizawa, M ^{[1
]}

Nakagawa, A ^{[1
]}

Nakano, S ^{[1
]}

Kigoshi, T ^{[1
]}

Uchida, K ^{[1
]}

机构：

[1] Kanazawa Med Univ, Dept Internal Med, Div Endocrinol, Ishikawa 9200293, Japan

来源：

FEBS LETTERS | 2002年 / 530卷 / 1-3期

关键词：

testosterone; vascular cell adhesion molecule-1; atherosclerosis; nuclear factor-kappa B;

D O I：

10.1016/S0014-5793(02)03440-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated the effect of testosterone (T) on tumor necrosis factor-a (TNF-alpha)-induced expression of vascular cell adhesion molecule-1 (VCAM-1) in human aortic endothelial cells. Incubation of these cells with T resulted in a dose-dependent reduction in the expression, with this reduction completely abolished by a selective androgen receptor blocker. Electrophoretic mobility shift assay demonstrated that T inhibited TNF-alpha-induced activation of the transcriptional nuclear factor-kappaB, which is critical for the inducible expression of VCAM-1, probably through the suppression of the nuclear translocation. Our results may suggest an inhibitory effect of T on atherogenesis, providing a novel insight into the consideration of the pathogenesis of atherosclerosis. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：129 / 132

页数：4

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