Increased levels of expression of an NMDARI splice variant in the superior temporal gyrus in schizophrenia

被引：38

作者：

Le Corre, S ^{[1
]}

Harper, CG

Lopez, P

Ward, P

Catts, S

机构：

[1] Univ Sydney, Dept Pathol, Sydney, NSW 2006, Australia

[2] Univ New S Wales, Sch Psychiat, Sydney, NSW, Australia

来源：

NEUROREPORT | 2000年 / 11卷 / 05期

关键词：

gene expression; in situ hybridization histochemistry; NMDARI; schizophrenia; splice variants; superior temporal gyrus;

D O I：

10.1097/00001756-200004070-00017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Expression patterns of mRNAs for the NMDAR1 subunit (NRI) carboxy-terminus isoforms were investigated in postmortem brain tissue using isotopic in situ hybridization. Three brain regions (superior temporal, middle frontal and visual cortices) were examined in patients with schizophrenia (n = 6) and control subjects (n = 6). A 22% higher level of expression of the NRI isoform that contains neither spliced exon was observed in the superior temporal gyrus of patients with schizophrenia compared with controls (p=0.01). No differences were observed in the expression of the other isoforms in the three regions studied. These data suggest that NRI alternative splicing might be abnormal in schizophrenia and reinforce previous findings implicating the superior temporal gyrus as a site of neural dysfunction in schizophrenia. NeuroReport 11:983-986 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：983 / 986

页数：4

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