Nerve growth factor antibody exacerbates neuropathological signs of experimental allergic encephalomyelitis in adult Lewis rats

被引：42

作者：

Micera, A ^{[1
]}

Properzi, F ^{[1
]}

Triaca, V ^{[1
]}

Aloe, L ^{[1
]}

机构：

[1] CNR, Inst Neurobiol, I-00137 Rome, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2000年 / 104卷 / 02期

关键词：

EAE; NGF-deprived rats; chronic relapsing; BDNF; multiple sclerosis; inflammation; restorative events;

D O I：

10.1016/S0165-5728(99)00272-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study, experimental allergic encephalomyelitis (EAE) rats and rats exhibiting EAE expressing high circulating anti-nerve growth factor antibody were daily monitored for clinical signs and chronic relapses. Eighty-Five days after EAE induction, blood, spinal cord and brain stem were used for histological examination, nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) evaluation. The results showed that NGF-deprived rats display more severe clinical signs of disease. These effects were associated with a significant reduction of NGF in the brain stem and spinal cord but not of BDNF. which decreased only in spinal cord. These observations provide additional support to the hypothesis of a protective NGF role in rats exhibiting EAE. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：116 / 123

页数：8

共 46 条

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Aloe L, 1998, ARCH ITAL BIOL, V136, P247

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