RIP Kinases at the Crossroads of Cell Death and Survival

被引：580

作者：

Declercq, Wim ^{[1
,2
]}

Vanden Berghe, Tom ^{[1
,2
]}

Vandenabeele, Peter ^{[1
,2
]}

机构：

[1] VIB, Dept Mol Biomed Res, Mol Signaling & Cell Death Unit, B-9052 Ghent, Belgium

[2] Univ Ghent, Dept Biomed Mol Biol, B-9052 Ghent, Belgium

来源：

CELL | 2009年 / 138卷 / 02期

关键词：

NECROSIS-FACTOR RECEPTOR-1; KAPPA-B ACTIVATION; TNF-ALPHA; PATHWAY; IDENTIFICATION; NECROSTATINS; DOMAIN; SIGNAL;

D O I：

10.1016/j.cell.2009.07.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Protein kinases of the receptor interacting protein (RIP) family collaborate with death receptor proteins to regulate cell death. Recent studies (Cho et al., 2009; He et al., 2009; Zhang et al., 2009) reveal that the RIP3 kinase functions with RIP1 at the crossroads of apoptosis, necroptosis, and cell survival.

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收藏

页码：229 / 232

页数：4

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